Figure 1.

Prehospital plasma resuscitation improves outcome in traumatic brain injury (TBI) patients

Critical trauma leads to a “Systemic Storm” caused by release of several cellular constituents including cytokines and metabolites into the circulation, and a “Massive Consumption” pattern associated with an increase in lipids, coagulation factors, and enzymes in the circulation. Prehospital plasma resuscitation in the PAMPer trial attenuated both the Systemic Storm and Massive Consumption patterns and improved survival in TBI patients with endothelial injuries. EC, endothelial cell; RBC, red blood cell.