Table 1.
Reproductive outcomes of euploid and mosaic embryos
| Group A: Euploid | Group B: Low-grade mosaic (20–30% variation) | Group C: Medium-grade mosaic (30–50% variation) | Adjusted OR (95% CI; p value) | |
|---|---|---|---|---|
| Test sets, n | 484 | 282 | 131 | - |
| Positive pregnancy test, % (n) | 55.8% (270/484) | 55.0% (155/282) | 55.7% (73/131) | 0.98 (0.75–1.27; 0.86) |
| Biochemical pregnancy loss, % (n) | 10.7% (29/270) | 12.3% (19/155) | 13.7% (10/73) | 1.18 (0.69–2.02; 0.53) |
| Miscarriage, % (n) | 12.0% (29/241) | 11.0% (15/136) | 12.7% (8/63) | 0.89 (0.50–1.55; 0.69) |
| Live birth, % (n) | 43.4% (210/484) | 42.9% (121/282) | 42.0% (55/131) | 0.97 (0.74–1.26; 0.82) |
| Monochorial twins delivery, n | 1 | 1 | 1 | - |
| Gestational age, mean (95% CI) | 38.4 (38.0–38.7) | 38.2 (37.9–38.6) | 38.1 (38.0–38.5) | - |
| Birth weight, mean (95% CI) | 3,286 (3,200–3,371) | 3,174 (3,080–3,267) | 3,130 (2,950–3,310) | - |
Biochemical pregnancy is defined by a positive pregnancy test. Implantation rate is defined as the number of gestational sacs observed by vaginal ultrasound at the fifth gestational week divided by the number of embryos transferred. Multiple pregnancy is defined by any scan with more than one heartbeat or gestational sac at the stage of clinical pregnancy (approximately 6 weeks). Miscarriage is defined as the loss of a clinical pregnancy, excluding ectopic pregnancies, before 20 weeks of gestation. A live birth is defined as a delivery that resulted in at least one live birth after 22 weeks of gestation. CI denotes confidence interval. “-” indicates not applicable.