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. 2021 Oct 26;120(23):5355–5370. doi: 10.1016/j.bpj.2021.10.026

Figure 1.

Figure 1

The general IgG1 architecture and the comparison between human and CHO cell glycosylation patterns. (A) IgG1 structural organization: in blue, HCs, divided into variable (VH) and constant (CH1, CH2, CH3) domains; in gray, LCs, organized into one variable (VL) and one constant (CL) domain; interchain disulphide bonds are represented as yellow sticks. (B) Glycosylation patterns expressed in human versus those expressed in CHO cells, including G0 and G0F glycans used in this study. In both panels, sugars are represented according to the Symbol Nomenclature for Glycans (4). To see this figure in color, go online.