Figure 4.

RMSD and RMSF of Fc and distances distribution between CH2 domains. (A) The RMSD computed for Cα atoms of Fc portions and (B) the RMSF analysis show quite overlapping trends among the three Fc, with a higher fluctuation in the first CH2 region of G0 mAb. (C) Box plots of Asn301-Asn301 Cα distances computed in the last 6000 timeframes, showing the higher opening of G0 Fc. On the y axis, distances are reported in nanometers, and on the x axis, the antibody species is given. Outliers are shown as diamonds. (D) Structural superposition of medoid structures with median values of each distribution. To see this figure in color, go online.