Figure 2.
Manhattan plot and qq-plot of results from GWAS of European-ancestry individuals predicted by PheML to exhibit developmental stuttering
Analysis included 7,751,954 variants across chromosomes 1–22. One locus in chromosome 2 reached genome-wide significance (p < 5 × 10−8); the sentinel variant, rs12613255 (BETA = 0.323; p = 1.31 × 10−8), was 113 kb 3' of CYRIA (FAM49A is an alias for CYRIA). The red line indicates the threshold for genome-wide significance (5.0 × 10−8), and the blue line indicates the threshold for suggestive significance (1.0 × 10−5). Loci reported in Table 4 are labeled on the plot as well as the nearest gene.