Figure 4.
Manhattan plot and qq plot of results from GWAS of African-ancestry individuals predicted by PheML to exhibit developmental stuttering
Analysis included 13,643,593 variants across chromosomes 1–22. One variant, rs7837758, reached genome-wide significance (BETA = 0.518; p = 5.07 × 10−8), on chromosome 8 within the third intron of ZMAT4. The red line indicates the threshold for genome-wide significance (5.0 × 10−8), and the blue line indicates the threshold for suggestive significance (1.0 × 10−5). Loci reported in Table 4 are labeled on the plot as well as the nearest gene.