Figure 7.

Cluster versus single-trait power analysis

Power comparison of genes with ${\text{log}}_{10}$ BF $\ge$ 5 in either (i) any of the single-trait analyses of the traits within the cluster or (ii) the multi-trait analysis for a cluster of biomarkers (alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, glucose, HbA1c, total protein, apolipoprotein B, cholesterol, LDL-C, and non-albumin protein). x axis depicts the maximum ${\text{log}}_{10}$ BF of the gene among any of the constituent single-trait analyses, and y axis depicts the multi-trait result. Multi-trait analyses roughly equal the highest-powered single-trait analyses while also substantially boosting signal in some genes.