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Schematic model showing the tumor-suppressive role of KDM6A in PDAC progression. KDM6A deficiency leads to the increased expression of activin A. Activin A activates a noncanonical p38 MAPK pathway, which induces mesenchymal identity, tumor sphere formation, cell migration, and invasion in PDAC cells. This signaling promotes the formation of an aggressive type of PDAC with accelerated progression and metastasis.
