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. 2021 Nov 15;120(24):5544–5552. doi: 10.1016/j.bpj.2021.11.015

Figure 3.

Figure 3

(A) MD simulations of doubly tethered DNA (cyan) loaded with one asymmetric LEF (violet and red) extruding a loop (blue). (B) Mean relative DNA extension as a function of time. The relative extension is defined as the end-to-end distance divided by the difference between the total length of the DNA and the length of the extruded loop. (C) Extrusion rate as a function of time. (D) Extrusion rate as a function of tension: comparison between our simulations (dark-gray squares) and experimental data from (5) (cyan “+”).