Figure 3. IFN-γ response decreased from pregnancy to delivery and increased from delivery to 6 months postpartum regardless of HIV status.
Quantitative IFN-γ response (median IFN-γ concentration measured in TB antigen 1 tube using the QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold plus assay) to Mycobacterium tuberculosis antigen stimulation at each pregnancy stage in a longitudinal cohort of initially IGRA+ pregnant women with and without HIV in Pune, India. Response decreased from pregnancy to delivery (p<0.01) and increased from delivery to 6 months postpartum (p<0.01), regardless of HIV status. Women living with HIV had a lower IFN-γ response than women without HIV at all timepoints; the difference was significant during pregnancy and delivery, as indicated by the asterisk (p<0.01).
Error bar represents 95% confidence interval.