Table. Risk factors for the development of in-stent restenosis.

Patient-related risk factors	Stent-related risk factors	Lesion-related risk factors	Implantation-related risk factors
Diabetes mellitus (4, 17, 21)	BMS (versus DES) (4, 17)	Small target vessel (4, 17, 18)	Inadequate stent expansion (22– 25) – Stent malapposition to the vessel wall (24) – Reduced minimum lumen area in the stent (24) – Non-symmetric stent expansion (24)
Arterial hypertension (21)	First-generation DES (versus newer generations) (4, 17, 18)	Ostial lesion (21)	Final diameter stenosis (18)
Previous bypass surgery (17, 18)	Thick stent struts (4, 20)	Longer stented lesion (4, 17)
Heart failure (21)		Complex morphology of the lesion (4, 17)
		Length of the stenosis (>20mm) (21, 26)

BMS, bare metal stent; DES, drug-eluting stent