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. 2021 Jul 28;81(18):4808–4821. doi: 10.1158/0008-5472.CAN-21-1500

Figure 1.

Figure 1. F-PRT protects from morbidities and attenuates upregulation of pathways involved in keratinization and apoptosis, compared with S-PRT. A and B, Kaplan–Meier plots of survival following 30 Gy (A) and 45 Gy (B) of proton radiation, delivered to the mouse hind leg; n = 10, statistical analysis by log-rank test. Events record mortality or mandated euthanasia due to morbidity. C, Gene ontology enrichment analysis of the differentially expressed genes (upregulated) in the skin of S-PRT-treated mice compared with F-PRT-treated mice; n = 4 per group.

F-PRT protects from morbidities and attenuates upregulation of pathways involved in keratinization and apoptosis, compared with S-PRT. A and B, Kaplan–Meier plots of survival following 30 Gy (A) and 45 Gy (B) of proton radiation, delivered to the mouse hind leg; n = 10, statistical analysis by log-rank test. Events record mortality or mandated euthanasia due to morbidity. C, Gene ontology enrichment analysis of the differentially expressed genes (upregulated) in the skin of S-PRT-treated mice compared with F-PRT-treated mice; n = 4 per group.