Table 1.
Characteristics of canine patients and treatment parameters for FLASH or standard proton radiotherapy.
| Patient ID | Breed | Age (years) | Sex | Weight (kg) | Dose rate (Gy/s) | Dose (Gy) | FLASH or standard |
|---|---|---|---|---|---|---|---|
| 1 | Black Lab | 11.0 | F | 33.1 | 76.2 | 8.1 | F |
| 2a | St Bernard | 4.5 | M | 61.4 | 61.0 | 4.0 | F |
| 3 | Mastiff | 6.0 | F | 57.0 | 103.0 | 8.1 | F |
| 4 | Mastiff | 6.5 | M | 59.6 | 0.5 | 8.0 | S |
| 5 | Rottweiler | 8.0 | M | 55.2 | 111.5 | 8.0 | F |
| 6 | Mixed Breed | 8.0 | M | 25.2 | 0.5 | 8.1 | S |
| 7 | Doberman/Great Dane Mix | 5.5 | F | 45.9 | 0.5 | 8.1 | S |
| 8 | Mixed Breed | 7.0 | M | 29.8 | 111.5b | 7.6 | F |
| 9 | Golden Retriever | 9.0 | M | 40.2 | 114.8b | 8.0 | F |
| 10 | Shepherd Mix | 9.0 | M | 35.7 | 0.5b | 8.0 | S |
| 11 | Great Pyrenees | 9.0 | M | 42.9 | 101.9 | 12.1 | F |
| 12 | American Bulldog | 10.0 | M | 45.4 | 0.5 | 12.0 | S |
| 13a | Mixed Breed | 8.0 | F | 36.0 | 0.1c | 12.0 | S |
| 14a | Doberman | 8.0 | M | 36.5 | 95.5 | 12.0 | F |
| 15 | Labradoodle Mix | 10.0 | M | 42.5 | 122.3 | 11.9 | F |
| 16 | Great Dane | 5.0 | F | 71.0 | 0.5 | 12.0 | S |
| 17 | Rottweiler | 6.0 | F | 34.4 | 0.5 | 11.9 | S |
| 18 | Rottweiler/Husky | 10.0 | M | 46.3 | 128.2 | 12.0 | F |
| 19 | Greyhound | 1.5 | M | 28.0 | 0.6 | 11.9 | S |
aTGFβ not assayed in these animals.
bIrradiated with spread out Bragg peak (SOBP) protons.
cIrradiated with photons. See Materials and Methods for complete details.