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. Author manuscript; available in PMC: 2021 Dec 29.
Published in final edited form as: Annu Rev Anim Biosci. 2020 Sep 28;9:173–201. doi: 10.1146/annurev-animal-061220-023220

Figure 4.

Figure 4

Chromosome elimination during sea lamprey development. Embryos have an initial haploid chromosome number of N = 96. Chromosome elimination is initiated after the sixth cleavage division at one day postfertilization (dpf). Presomatic cells isolate 12 whole chromosomes that are packaged into micronuclei, which initially accumulate silencing marks on histones and then 5-methylcytosine. Primary nuclei show signs of epigenetic silencing later in development, at the time that eliminated chromosomes are being degraded within micronuclei.