Figure 5.

Dynamic networks of the apo, BI167107-, and salmeterol-bound β2AR with and without Nb80 bound are analyzed using community network analysis. (A–C) Two-dimensional (2D) networks of unliganded, BI167107- and salmeterol-bound forms with Nb80. (D–F) Two-dimensional (2D) networks of apo, BI167107-, and salmeterol-bound forms without Nb80. Network communities are colored separately according to their ID number. A community represents a set of highly intra-connected nodes (residues), its size being determined by the number of nodes included in a community. Edges connecting two communities are represented by lines, of which the width is proportional to the strength of the information flow between the connected communities.