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Optimal paths connecting the intracellular (C7) and extracellular binding sites (C1) in apo (A), BI167107 (B), and salmeterol (C)-bound β2AR-Nb80 structures. Residues are rendered as spheres and colored consistently with the communities they belong to in Figure 5, and the connecting edges are represented by lines with their width weighted by betweenness.
