Fig. 1.

Age at symptom onset, age at diagnosis, and time to diagnosis in patients with HAE-1/2 from Spain and from other countries participating in IOS. Lines within box plots represent median age in years, lower and upper lines of boxes represent the 25th and 75th percentiles, and box whiskers denote the minimum and maximum. The minimum time from symptom onset to diagnosis was −19.0 years in patients from Spain and −41.8 years in patients from other countries for patients diagnosed before symptom onset based on family history, genetic mutation analysis, concentration and/or functional testing of C1 inhibitor, or concentration of C4. HAE-1/2 hereditary angioedema due to C1 inhibitor deficiency, IOS Icatibant Outcome Survey, IQR interquartile range