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. Author manuscript; available in PMC: 2021 Dec 29.
Published in final edited form as: Brain Behav Immun. 2018 Aug 11;74:106–120. doi: 10.1016/j.bbi.2018.08.008

Fig. 7.

Fig. 7.

GCR induced changes in microglia phenotypes in male cohorts only. Microglia levels were measured by Iba-1 staining in the dorsal hippocampus. Representative images from MALE cohorts- 0 cGy DG (A), 50 cGy DG (B), 0 cGy CA2/3 (C) 50 cGy CA2/3 (D). (E) Males exposed to 50 cGy of triple ion had increased Iba-1 expression in the DG, CA1 and CA2/3. Two-way ANOVA revealed a significant region effect (p < 0.01), group effect (p < 0.001) and interaction (p < 0.01). Bonferroni post-hoc analysis reveals differences between groups. Representative images from FEMALE cohorts- 0 cGy DG (F), 50 cGy DG (G), 0 cGy CA2/3 (H) 50 cGy CA2/3 (I). (J) No differences in Iba-1 expression was measured. Two-way ANOVA revealed a significant region effect (p < 0.05) and interaction (p < 0.05), however Bonferroni post-hoc analysis did not reveal any differences between the groups. No reactivity was observed in secondary alone. 200x magnification. **p < 0.01. ***p < 0.001 Individual animal scores represented in dots, lines depict group mean and SEM. Scale bar = 100 μm denoted by white line in (A). Males n = 3–4; Females n = 4.