Table 5.
Group of Clinical Strains/Control Strain | Ceragenin | MIC range (µg/mL) | MIC50 (µg/mL) | MIC90 (µg/mL) | MBC range (µg/mL) | MBC50 (µg/mL) | MBC90 (µg/mL) |
---|---|---|---|---|---|---|---|
All clinical P. aeruginosa (n=150) |
CSA13 | 0.5–8 | 2 | 4 | 0.5–8 | 4 | 8 |
CSA44 | 0.5–8 | 2 | 4 | 0.5–8 | 4 | 8 | |
CSA131 | 0.5–4 | 1 | 2 | 0.5–8 | 2 | 4 | |
Group I (n=22) |
CSA13 | 1–4 | 2 | 4 | 1–8 | 4 | 8 |
CSA44 | 1–8 | 2 | 4 | 1–8 | 4 | 8 | |
CSA131 | 0.5–4 | 2 | 4 | 1–8 | 2 | 4 | |
Group II (n=40) |
CSA13 | 0.5–8 | 2 | 4 | 0.5–8 | 4 | 8 |
CSA44 | 1–4 | 2 | 4 | 1–8 | 2 | 8 | |
CSA131 | 0.5–4 | 1 | 2 | 0.5–8 | 2 | 4 | |
Group III (n=67) |
CSA13 | 0.5–4 | 2 | 4 | 0.5–8 | 4 | 8 |
CSA44 | 0.5–4 | 2 | 2 | 0.5–8 | 4 | 8 | |
CSA131 | 0.5–4 | 1 | 4 | 0.5–8 | 2 | 4 | |
Group IV (n=13) |
CSA13 | 1–4 | 2 | 4 | 1–8 | 4 | 4 |
CSA44 | 2–4 | 2 | 2 | 2–4 | 2 | 4 | |
CSA131 | 1–2 | 1 | 2 | 1–4 | 2 | 2 | |
Group V (n=8) |
CSA13 | 2–8 | 4 | 8 | 2–8 | 4 | 8 |
CSA44 | 2–4 | 2 | 4 | 2–8 | 4 | 8 | |
CSA131 | 0.5–2 | 1 | 2 | 1–2 | 1 | 2 | |
Pseudomonas aeruginosa ATCC 27853 | CSA13 | 2 | – | – | 2 | – | – |
CSA44 | 2 | – | – | 2 | – | – | |
CSA131 | 1 | – | – | 1 | – | – |