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. Author manuscript; available in PMC: 2021 Dec 29.
Published in final edited form as: Nat Genet. 2021 May;53(5):591–592. doi: 10.1038/s41588-021-00869-0

Figure 1. h5UTRs may act as key regulators of translation during vertebrate development.

Figure 1.

a, Hyperconserved 5’UTRs are enhancers of non-canonical expression with cell type-dependent activities. b, The Csde1 hyperconserved 5’UTR forms an ensemble of RNA conformations. The dynamics of this RNA folding landscape acts as a structure-dependent dimmer switch of non-canonical translation. This RNA dimmer switch may control the spatiotemporal translation of Csde1 during embryonic development.