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. 2021 Dec 29;11(12):e667. doi: 10.1002/ctm2.667

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© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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CLDN2‐mediated NDRG1 suppression modulates colon cancer cell behaviours by activating EMT and increasing CDK inhibitor expression. (A) Expression of the indicated EMT markers (E‐cadherin, Collagen I, Fibronectin, Vimentin, FAP and a‐SMA) in HCT116 and HT29 cells either overexpressing NDRG1 or knocking out NDRG1. (B, C) Expression of the indicated EMT markers in cells overexpressing NDRG1 or knocking out NDRG1. (D) Expression of CDK inhibitors including p16, p21 and p27 in HCT116 cells either overexpressing CLDN2 or HT29 cells knocking out CLDN2. (E, F) Expression of CDK inhibitors including p16, p21 and p27 in HCT116 and HT29 cells overexpressing NDRG1 and knocking out NDRG1. Similar results were repeated at least three times