TABLE 1.
Summary of clinical, pathologic, and molecular findings of four BRAF-fusions positive GIST
| Charo et al23 | Vanden Bempt et al3 | Case 1 | Case 2 | |
|---|---|---|---|---|
| Age | 34 | 64 | 40 | 37 |
| Gender | F | M | F | F |
| Site | Small intestine | Stomach | Small intestine | Esophagus |
| Size (cm) | 14 | 2.5 | 2.8 | 7.3 |
| Morphology | Spindle | Spindle | Spindle | Spindle |
| Mitotic rate | 3/50 HPF | ≤5/50HPF | 20/50 HPF | <1/50 HPF |
| IHC | CD117 positive DOG1 positive |
N/A | CD117 weakly pos DOG1 positive 18 mo NED |
CD117 negative DOG1 positive SMA positive Desmin rare pos ER negative 36 mo/NED |
| Fusion |
PRKAR1B-BRAF PRKAR1B exon 9-BRAF exon 9 |
TRIM4-BRAF TRIM4 exon 6-BRAF exon 10 |
AGAP3-BRAF AGAP3 exon 11-BRAF exon 10 |
MKRN1-BRAF MKRN1 exon 4-BRAF exon 11 |
| Survival/therapy | N/A | N/A | 18 mo NED Surgery |
36 mo NED Surgery |
Abbreviations: mo, months; NA, not available; NED, no evidence of disease; pos, positive.