TABLE 2.

Prenatal alcohol exposure modulates CAMs expression in ex vivo and in vivo experimental models.

CAM	Experimental model	Doses/treatment	Time of exposure	Effect
PSA-NCAM	Chick embryos	10 mg/50μl/day	E1-5	Increase of protein expression
PSA-NCAM	Rats	5% wt/vol	Before mating, during gestation and lactation	Increase of protein expression
NCAM-140, NCAM-180	Rats	5% wt/vol	Before mating, during gestation and lactation	Reduction of protein expression
NCAM-140, NCAM-180	Cultures of cortical neurons (16 day old fetuses)	400 mg/dl	48 h	Reduction of protein expression
L1	Cultures of cerebellar granule cells (PND8 rats)	5, 10, 25, 50 mM	90 min	Inhibition L1 cell-adhesion
L1	Cultures of cerebellar granule cells (PND6 rats)	3–5 mM	12 h	Inhibition L1- mediated neurite outgrowth
L1	Rats	6 g/kg/day	PND6	Increase in lipid rafts
NCAMs	Zebrafish	1% (vol/vol)	1 day after post-fertilization for 2 h	Reduction of protein expression
Cadherin-8	Mice	25% vol/vol	Gestation	Increase of protein expression
N-cadherin	Chick embryos	2% vol/vol	3 days	Increase of protein expression
N-cadherin	Mice	10% (w/vol)	17 days previous and up to day 10 of gestation	Increase of protein expression
α-integrins and β-integrin 3	Neural progenitor cells	1, 10, 100 mM	3 days	Increase of protein expression
β-integrin 2	Neural progenitor cells	1, 10, 100 mM	3 days	Decrease of protein expression