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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: FASEB J. 2021 Jul;35(7):e21665. doi: 10.1096/fj.202100543RR

FIGURE 2.

FIGURE 2

Macrophage TNF-α deficiency fails to improve obesity-linked metabolic dysfunction. Male TNF-αF/F and TNF-αF/F,LyzMCre consumed either a low-fat diet (LFD) or HFD for 18 weeks. A, 12-week fasting (5 hours) blood glucose (FBG), B, 12-week fasting (5 hours) plasma insulin, C, 17-week FBG (5 hours), D, 17-week fasting (5 hours) plasma insulin, E, glucose tolerance test (GTT) performed after ≈17 weeks of dietary treatment, F, insulin response to GTT, G, insulin tolerance test (ITT) performed after ≈18 weeks of dietary treatment, H, and I, serum free-fatty acid (FFA) concentration following a 5-hour fast measured at 0 and 30 minutes of the ITT, respectively, J, change in serum FFAs from 0 to 30 minutes of the ITT (n = 16–28/group). Data are presented as mean ±SE. Bar graphs not sharing a common letter are significantly different from one another (P < .05). Colored asterisks* represent statistically significant differences from the respective group’s baseline glucose levels (P < .05). ME = Main Effect