TABLE 1.
Adipose tissue gene pathway changes as a result of macrophage TNF-α deficiency
| Pathway | P-value | Gene # Changed | Up | Down | Net |
|---|---|---|---|---|---|
| Purine nucleotide metabolic process | .001056 | 35 | 24 | 11 | 13 |
| Purine ribonucleotide metabolic process | .001598 | 32 | 22 | 10 | 12 |
| Purine-containing compound metabolic process | .001598 | 36 | 24 | 12 | 12 |
| Ribose phosphate metabolic process | .001598 | 33 | 23 | 10 | 13 |
| Generation of precursor metabolites and energy | .001598 | 36 | 25 | 11 | 14 |
| Ribonucleotide metabolic process | .001631 | 32 | 22 | 10 | 12 |
| Nucleotide metabolic process | .014057 | 35 | 23 | 12 | 11 |
| Tumor necrosis factor production | .017636 | 19 | 5 | 14 | −9 |
| Nucleoside phosphate metabolic process | .017852 | 35 | 22 | 13 | 9 |
| Tumor necrosis factor superfamily cytokine production | .017852 | 19 | 5 | 14 | −9 |
| Pyruvate metabolic process | .017852 | 15 | 11 | 4 | 7 |
| Toll-like receptor signaling pathway | .018458 | 14 | 3 | 11 | −8 |
| I-kappa B kinase/NF-kappa B signaling | .025883 | 20 | 7 | 13 | −6 |
| Regulation of tumor necrosis factor production | .025962 | 18 | 5 | 13 | −8 |
| Regulation of I-kappa B kinase/ NF-kappa B signaling | .026226 | 18 | 7 | 11 | −4 |
| Regulation of tumor necrosis factor superfamily cytokine production |
.026591 | 18 | 5 | 13 | −8 |
| Nucleobase-containing small molecule metabolic process | .032999 | 37 | 24 | 13 | 11 |
| Purine nucleotide biosynthetic process | .033123 | 17 | 9 | 8 | 1 |
| Coenzyme A metabolic process | .033123 | 5 | 4 | 1 | 3 |
Note: 19 pathways were found to be significantly changed (P < .05) as a result of macrophage TNF-α deletion.