Figure 6. Decoupling host environment with nerve abundance using the neural-modified accessory limb model (NM-ALM).

(A) The traditional ALM (as used in Figure 5) requires a blastema donor and a host animal with a nerve bundle deviated to the wound site. (B) The NM-ALM requires a GFP+ dorsal root ganglia (DRG) donor, blastema donor, and host limb with a wound site. (B’) The DRG’s GFP+ axons regenerate and innervate the ectopic limb.