Table 1:

Demographic Characteristics and Neuropsychological Results for the Late-Life Depressed (LLD) Patients and Controls

	Healthy, Older Controls (n = 20)	LLD Patients (n = 20) at Baseline (Prior to SSRI Treatment)	LLD Patients (n = 19) During SSRI Treatment
Age	66 ± 6	67 ± 6
Sex (F/M)	11/10	11/10
Education (in years)	15 ± 3	16 ± 2
MMSE	29 ± 1	29 ± 1	29 ± 1
HAMD	1 ± 1	18 ± 2a	5 ± 3c*
BDI	6 ± 12	24 ± 8b	7 ± 2d*
CVLT Total Recall (Sum of first 5 Trials)	59 ± 12	57 ± 10	58 ± 10
CVLT Delayed Free Recall	12 ± 2	12 ± 3	13 ± 3
BVMT-R Total Recall (Sum of first 3 Trials)	19 ± 7	20 ± 8	24 ± 7e
BVMT-R Delayed Recall	8 ± 3	7 ± 3	9 ± 3e
Rey Complex Figure Test- Copy	32 ± 3	31 ± 4	32 ± 3
Rey Complex Figure Test- Immediate Recall	17 ± 6	15 ± 7	21 ± 7f
Rey Complex Figure Test- Delayed Recall	16 ± 5	14 ± 6	21 ± 7g
DKEFS™ Letter Fluency	44 ± 12	40 ± 12	46 ± 12
DKEFS™ Category Fluency	41 ± 8	42 ± 8	42 ± 8

BDI, Beck Depression Inventory; BVMT-R, Brief Visual Memory Test-Revised; CVLT, California Verbal Learning Test, D-KEFS™, Delis-Kaplan Executive Function System™; HAMD, Hamilton Depression Rating Scale; MMSE, modified Mini-Mental State Examination; SSRI, Selective Serotonin Reuptake Inhibitor.

^*tests performed prior to the PET scan.

^aSignificant between group difference (F(1,18)=205.6, P = 0.000)

^bSignificant between group difference (F(1,18)=38.00, P = 0.000)

^cSignificant difference in the LLD patients before and during SSRI treatment (F(1,18)=229.31, P = 0.000)

^dSignificant difference in the LLD patients before and during SSRI treatment (F(1,18)=42.52, P = 0.000)

^eSignificant difference in the LLD patients before and during SSRI treatment (F(1,18)= 14.06, P = 0.001)

^fSignificant difference in the LLD patients before and during SSRI treatment (F(1,18)=33.80, P = 0.000)

^gSignificant difference in the LLD patients before and during SSRI treatment (F(1,18)= 61.10, P = 0.000)