Table 4: Lower Serotonin Transporter Availability in Late-Life Depressed (LLD) Patients scanned prior to starting antidepressant treatment Compared to Demographically-Matched Controls: Voxel Wise Analysis.
Sample Size (n=20).
| Left Hemisphere | Right Hemisphere | |||||
|---|---|---|---|---|---|---|
| MNI1 Coordinates | Talairach Coordinates | Z-Score | MNI Coordinates | Talairach Coordinates | Z-Score | |
| X Y Z (mm) | X Y Z (mm) | Structure | X Y Z (mm) | X Y Z (mm) | ||
| −18 −12 −20 | −18 −8 −15 | 3.63 | Lateral Orbital Gyrus (BA 11) | |||
| Insula | 38 −2 −20 | 3.23 | ||||
| −48 −14 −24 | −45 −14 −17 | 3.90 | Superior Temporal Gyrus (BA 38) | |||
| −44 −4 −14 | −42 −7 −8 | 3.54 | Superior Temporal Gyrus (BA 22) | |||
| Middle Temporal Gyrus (BA 20/21) | 66 −16 −22 | 62 −19 −14 | 3.10 | |||
| −44 −10 −34 | −42 −13 −26 | 3.12 | Inferior Temporal Gyrus (BA 20) | 56 −12 −32 | 53 −15 −24 | 3.52 |
| −28 −16 −28 | −27 −14 −23 | 4.24 | Parahippocampal Gyrus ( BA 36) | 30 −12 34 | 27 −10 −27 | 4.40 |
| −26 0 −30 | −26 −3 −23 | 3.09 | Parahippocampal Gyrus ( BA 36) | |||
| Amygdala | 30 −6 −14 | 3.50 | ||||
| −30 0–42 | −28 2 −34 | 3.89 | Fusiform Gyrus (BA 37/20) | 32 0 40 | 29 2 −31 | 4.25 |
Significant between-group comparisons are reported at a cluster-level, family-wise error (FWE) corrected threshold of p = 0.000 and a peak voxel uncorrected threshold of p ≤ 0.001: Height threshold p=0.01 and extent threshold (k) =50 voxels. The cluster size (kE) is 6875. BA, Brodmann area; MNI, Montreal Neurological Institute (MNI). Sample Size (n=20).