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. Author manuscript; available in PMC: 2022 Aug 15.
Published in final edited form as: Neuropharmacology. 2021 Jan 12;194:108447. doi: 10.1016/j.neuropharm.2021.108447

Table 6a:

Correlation between 5-HTT Occupancy in Late-Life (LLD) Depressed Patients and the Change in Depressive Symptoms (Beck Depression Inventory)

Left Hemisphere Right Hemisphere
MNI Coordinates Talairach Coordinates Z-Score MNI Coordinates Talairach Coordinates Z-Score
X Y Z (mm) X Y Z (mm) Structure X Y Z (mm) X Y Z (mm)
−14 −30 44 −13 −28 41 3.20 Paracentral Lobule (BA 5)
−8 −24 38 −7 −22 36 3.40 Posterior Cingulate Gyrus (BA 31) 0 −10 30 0 −9 29 3.57

Significant correlations are reported at a cluster-level, family-wise error (FWE) corrected threshold of p = 0.036 and a peak voxel uncorrected threshold of p ≤ 0.001: Height threshold p=0.01 and extent threshold (k) =50 voxels. The cluster size (kE) is 1509. BA, Brodmann area; MNI, Montreal Neurological Institute (MNI). Sample Size (n=19) LLD patients treated with Citalopram (n=16) and Sertraline (n=3) included.