Table 6b:
Correlation between 5-HTT Occupancy in Late-Life Depressed (LLD) Patients and the Change in Visual-Spatial Memory (Brief Visual Memory Test-Revised)
| Left Hemisphere | Right Hemisphere | |||||
|---|---|---|---|---|---|---|
| MNI Coordinates | Talairach Coordinates | Z-Score | MNI Coordinates | Talairach Coordinates | Z-Score | |
| X Y Z (mm) | X Y Z (mm) | Structure | X Y Z (mm) | X Y Z (mm) | ||
| −32 −10 14 | −31 −11 15 | 3.52 | Insula (BA 13) | 38 −14 12 | 36 −14 14 | 3.63 |
| −32 −22 8 | −30 −22 10 | 3.36 | Insula (BA 13) | 42 6 −16 | 40 1 −9 | 3.09 |
| −38 0 8 | −36 −2 10 | 3.24 | Insula (BA 13) | |||
| Superior Temporal Gyrus (BA 22) | 46 −10 −8 | 43 −12 −2 | 3.67 | |||
| Middle Temporal Gyrus (BA 22) | 52 −16 −12 | 49 −18 −6 | 3.40 | |||
| Inferior Temporal Gyrus (BA 20) | 56 −28 −26 | 53 −30 −18 | 4.07 | |||
| −48 −26 10 | −45 −26 12 | 3.08 | Transverse Temporal Gyrus | 42 −18 6 | 40 −19 9 | 3.85 |
| −8 −58 10 | −7 −56 12 | 3.39 | Precuneus (BA23) | 14 −52 24 | 14 −50 24 | 3.85 |
| −2 −12 30 | −1 −11 29 | 3.09 | Posterior Cingulate (BA 23) | 10 −24 36 | 10 −22 34 | 4.03 |
| −34 −48 −16 | −32 −49 −9 | 3.08 | Fusiform Gyrus (BA 37) | 48 −44 −16 | 46 −45 −9 | 3.41 |
| −48 −26 10 | −45 −26 12 | 3.08 | Supramarginal Gyrus (BA 40) | 56 −24 20 | 54 −23 21 | 3.73 |
| Supramarginal Gyrus (BA 40) | 44 −24 16 | 42 −24 17 | 3.25 | |||
| −2 −12 30 | 3.09 | Posterior Cingulate | ||||
| Pericalcarine Gyrus | 24–66 10 | 24–64 12 | 3.71 | |||
| Pericalcarine Gyrus | 22 −68 6 | 22 −66 9 | 3.68 | |||
| Pericalcarine Gyrus (BA 23) | 18 −60 8 | 18–58 11 | 3.24 | |||
| Isthmus/Cingulate (BA 18) | 10 −424 | 10 −42 7 | 3.17 | |||
| Lingual Gyrus (BA 18) | 14 −544 | 14 −53 7 | 3.14 | |||
| −28 −20 −8 | −27 −21 −3 | 3.34 | Hippocampus | |||
| −26 6 4 | 3.42 | Putamen | 28 4 6 | 3.91 | ||
| Putamen | 30 −14 4 | 3.43 | ||||
| −26 −16 −4 | 3.31 | Globus Pallidus | 20 −6 6 | 3.08 | ||
| −24 −10 8 | 3.22 | Globus Pallidus | ||||
| −22 −24 12 | 3.83 | Thalamus | 22 −28 2 | 3.22 | ||
| −14 −16 4 | 3.24 | Thalamus | ||||
Significant correlations are reported at a cluster-level, family-wise error (FWE) corrected threshold of p = 0.000 and a peak voxel uncorrected threshold of p ≤ 0.001: Height threshold p=0.01 and extent threshold (k) =50 voxels. The clustersize (kE) is 15029. BA, Brodmann area; MNI, Montreal Neurological Institute (MNI). Sample Size (n=19) LLD patients treated with Citalopram (n=16) and Sertraline (n=3) included.