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. 2021 Dec 30;355:131324. doi: 10.1016/j.snb.2021.131324

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Fig. 5 — Evaluation of the cross-reactivity between SARS-CoV-2 and influenza A/H1N1 using a dual-mode SERS-based aptasensor. The internal standard Raman reporter 4-MBA was immobilized on the Au nanopopcorn substrate. (a) Addition of SARS-CoV-2 lysate to a dual aptamer-immobilized Au popcorn substrate. (b) Average Raman spectra in the presence of various SARS-CoV-2 lysate (0.32−200 PFU/mL) concentrations and (c) the variations of the I₁₄₇₀/I₁₀₇₅ and I₁₆₅₀ /I₁₀₇₅. (d) Addition of influenza A/H1N1 lysate to a dual aptamer-immobilized Au popcorn substrate. (e) Average Raman spectra in the presence of various influenza/H1N1 lysate (0.13−80.6 HAU/mL) concentrations and (f) the variations of the I₁₄₇₀/I₁₀₇₅ and I₁₆₅₀ /I₁₀₇₅.