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. 2021 Dec 22;2021:4525988. doi: 10.1155/2021/4525988

Figure 5.

Figure 5

The effects of caspase-1 inhibitor VX765 on lung injury and inflammation. (a–h) Mouse lung tissue and serum were collected from each group for the following experiments. (a) The pathology score was evaluated by H&E staining. Scale bar, 100 μm. (b) Lung damage was evaluated based on H&E images. (c) IL-6 mRNA levels measured by RT-qPCR. (d, e) IL-6 protein levels measured in lung and serum by ELISA. (f) TNF-α mRNA level measured by RT-qPCR. (g, h) TNF-α protein level in lung and serum measured by ELISA. The data are expressed as mean ± SEM (n = 7 per group). VX765 = 30 mg/kg. ∗P < 0.05 vs. control. #P < 0.05 vs. I/R.