. Author manuscript; available in PMC: 2021 Dec 30.

Published in final edited form as: Toxicology. 2020 May 11;440:152478. doi: 10.1016/j.tox.2020.152478

Table 2.

Michaelis-Menten Kinetic Constants for Sudoxicam and Meloxicam Metabolites from Human Liver Microsome Reactions.

		Steady-state kinetic constants for individual metabolites^a
Substrate	Metabolite	V_max1^b	K_m1 (μM)	V_max/K_m1	V_max2^b	K_m2 (μM)	V_max/K_m2
sudoxicam	glyoxal	13 ± 0.75	5.9 ± 1.2	2.2	NA	NA	0.021 ^c
meloxicam	methylglyoxal	8.4 ± 0.39	26 ± 4.9	0.32	NA	NA	NA
	5-hydroxymethyl-meloxicam	29 ± 2.0	15 ± 2.9	1.9	NA	NA	0.014 ^c
		34 ± 24^d	14 ± 9.5^d	2.4	140 ± 84^d	380 ± 55^d	0.37

Best fit models shown in Fig. 4 were determined using corrected Akaike information criterion. Values shown with standard error from mean.

Units are pmol/min/mg protein.

Efficiency estimated based on slope of linear function.

Data reported by others (Chesne et al., 1998).