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. 2022 Jan;23(1):125–137. doi: 10.1016/S1470-2045(21)00470-8

Figure 1.

Figure 1

Trial profile of the titration study with embedded randomisation

COPP=cyclophosphamide, vincristine, prednisone, and procarbazine. ERA=early response assessment. ITT=intention to treat. RCT=randomised controlled trial. TG1=treatment group 1. TG2=treatment group 2. TG3=treatment group 3. *One patient initially assigned to TG2 was downstaged and treated as being in TG1 according to the local investigator's discretion. COPDAC=cyclophosphamide, vincristine, prednisone, and dacarbazine.