Figure 7.

In vitro study of IFNAR1, IFNAR2, sIFNAR2 and MxA gene expression. Representation of RNA relative expression of IFNAR1, IFNAR2, sIFNAR2 and MxA in PBMC from untreated MS patients cultured with or without IFN-β stimulus (N=7) during 8 and 24 hours. (A) sIFNAR2 expression in PBMC from each patient after 24 hours of culture in the presence or in the absence of IFN-β. (B) Boxplots comparing sIFNAR2 and MxA expression in unstimulated PBMC and IFN-β-stimulated PBMC during 8 and 24 hours of culture. Significant p values are marked with an asterisk. Logarithms are used to normalize and scale data for representation.