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. 2021 Dec 16;11:683915. doi: 10.3389/fonc.2021.683915

Figure 2.

Figure 2

Evaluation of the predictive efficacy of the signature for laryngeal cancer recurrence in the training set. (A) Heat maps depicting the expression patterns of these eight genes including RCN1, LAT2, DAPK2, DNAJA2, FUZ, LASP1, IBSP and HOOK2 between high- and low- risk score group. Red: up-regulation and blue: down-regulation. (B) Ranking of risk scores among all laryngeal cancer patients. (C) Distribution of recurrence time among all laryngeal cancer patients. Red dots express recurrence laryngeal cancer samples and blue dots represent non-recurrence samples. The dotted line indicates the optimal cutoff value of risk score. The left side of the line represents low-risk patients, while the right side represents high-risk patients. (D) Recurrence-free survival between high- and low- risk score groups. (E) ROC curve for predicting the patients’ 1-year recurrence. (F) ROC curves for predicting the patients’ 3 and 5-year recurrence. (G) ROC curves for prediction of 1, 3- and 5-year OS outcome.