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. 2021 Dec 16;15:780500. doi: 10.3389/fnbeh.2021.780500

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Copyright © 2021 Khom, Nguyen, Vandewater, Grant, Roberto and Taffe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representative mIPSCs from CeA neurons during control and during superfusion with the KOR-agonist U-50488 (1 μM, upper panel) or the KOR-antagonist norBNI (200 nM, lower panel) are shown. Bars represent means ± S.E.M of the normalized effects either (B) U-50488 or (C) norBNI at the indicated concentration on mIPSC characteristics. Statistically significant differences to baseline control were calculated using a one-sample t-test. (*) = P < 0.05, (***) = P < 0.001, (****) = P < 0.0001.