Table 2.

Small polar metabolites with signficant change between study start and follow-up in the total surgery group (n = 15).

Metabolite (relative concentration)	At study start	At follow-up	p-value	q-value
ID no. 400	6.45 ± 1.56	39.89 ± 37.04	0.00012	0.026
3-indoleacetic acid	57.34 ± 53.48	309.37 ± 362.84	0.00016	0.018
ID no. 493	9.31 ± 4.88	17.71 ± 5.79	0.00018	0.013
ID no. 361	7.21 ± 3.63	37.23 ± 35.10	0.00022	0.012
ID no. 294	565.07 ± 194.45	349.27 ± 194.06	0.00030	0.013
2-hydroxybutyric acid	399.49 ± 209.60	164.03 ± 85.83	0.00039	0.014
Valine	574.80 ± 131.67	395.01 ± 109.86	0.00075	0.023
ID no. 296	182.64 ± 66.16	343.78 ± 144.47	0.0012	0.033
ID no. 580	13.90 ± 9.77	32.91 ± 17.23	0.0016	0.039
Glutamic acid	244.25 ± 85.84	141.77 ± 80.66	0.0017	0.037
4 hydroxybenzeneacetic acid	22.83 ± 31.43	152.01 ± 164.83	0.0017	0.034
Alpha tocopherol	28.75 ± 9.11	19.62 ± 8.40	0.0019	0.036

The data are presented as mean relative concentration ± standard deviation. Paired T-test on log2-transformed values was used to analyse differences in metabolite levels at study start and follow-up. False discovery rate was used to adjust for multiple testing.