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. 2021 Dec 16;12:755623. doi: 10.3389/fimmu.2021.755623

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Copyright © 2021 Le Gallou, Lhomme, Irish, Mingam, Pangault, Monvoisin, Ferrant, Azzaoui, Rossille, Bouabdallah, Damaj, Cartron, Godmer, Le Gouill, Casasnovas, Molina, Houot, Lamy, Tarte, Fest and Roussel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circulating cMO and iMO share a common inflammatory phenotype, in DLBCL. (A) Unsupervised hierarchical clustering of classical- (cMO) and intermediate- (iMO) monocytes, from HD (n = 4) and DLBCL (n = 7) samples. See Table S3 for a list of genes analyzed on monocyte subsets after cell sorting. Pearson’s correlation and complete linkage was employed. (B) Transcripts differentially expressed (P <.05; ∣log2FC∣ > 1) between DLBCLs and HDs, for cMO and iMO. (C) Predicted top 5 biological processes increased for cMO and iMO from DLBCL (Ingenuity Pathway Analysis, z-score > 2.5, ranked by p-value). (D) Mean fluorescence (MFI) for CD64, HLA-DR, CD163, CD14, CD16, and CCR2 for HD (n = 16) and DLBCL (n = 33) samples. Mann-Whitney test were performed. *P < .05, **P < .01, ***P < .001, ns, non-significant.