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. 2021 Dec 16;8:793040. doi: 10.3389/fmed.2021.793040

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Copyright © 2021 Laurenzana, Trino, Lamorte, De Stradis, Santodirocco, Sgambato, De Luca and Caivano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MM-EV characterization. (A) Representative histogram of hydrodynamic EV size distribution profile from RPMI 8226 cell line measured by NTA. (B) NTA data are expressed as D10, D90, mode, mean, and concentration of MM-derived EVs as mean value ± Standard Error. (C) Representative photos of MM cell line-derived EVs obtained by TEM (image magnification: 100 and 160 KX, respectively). The horizontal bar indicates 50 and 25 nm, respectively. MM, multiple myeloma; EVs, Extracellular vesicles; NTA, Nanoparticle Tracking Analysis.