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. 2021 Dec 16;8:793040. doi: 10.3389/fmed.2021.793040

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Copyright © 2021 Laurenzana, Trino, Lamorte, De Stradis, Santodirocco, Sgambato, De Luca and Caivano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MM-EV effect on HSPC colony formation. (A) Representative photos of colony-forming unit (CFU) assay for HSPCs after 20 h of treatment with MM-EVs 400 μg (left) and means of the total number of colonies after treatment with two doses of MM-derived EVs (MM-EVs 200 μg, MM-EVs 400 μg; right); (B) representative photos of CFU-Granulocyte, Macrophage (CFU-GM), CFU Macrophage (CFU-M), CFU Granulocyte (CFU-G), CFU Granulocyte, Erythrocyte, Macrophage, Megakaryocyte (CFU-GEMM), and Burst-Forming-Unit Erythrocyte (BFU-E) after treatment with MM-EVs 400 μg; means of the total number (C) and proportion (D) of all type of colony after treatment with two doses of MM-derived EVs. The bar graphs represent the average with SD from three independent experiments. MM, multiple myeloma; EVs, Extracellular vesicles; HSPC, hematopoietic stem and progenitor cells.