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. 2021 Dec 16;8:793040. doi: 10.3389/fmed.2021.793040

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Copyright © 2021 Laurenzana, Trino, Lamorte, De Stradis, Santodirocco, Sgambato, De Luca and Caivano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MM-EV effect on CXCR4 expression on HSPCs. Percentage of CXCR4 expression on CD34⁺, CD34⁺/CD38⁻, and CD34⁺/CD38⁺ cells after 20 h of treatment with two doses of MM-derived EVs (MM-EVs 200 μg, MM-EVs 400 μg). The bar graphs represent the average with standard deviation from three independent experiments. MM, multiple myeloma; EVs, Extracellular vesicles; HSPC, hematopoietic stem and progenitor cells.