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. 2021 Dec 16;8:793040. doi: 10.3389/fmed.2021.793040

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Copyright © 2021 Laurenzana, Trino, Lamorte, De Stradis, Santodirocco, Sgambato, De Luca and Caivano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA alteration in HSPCs after MM-EV interaction. (A) Digital PCR analysis for miR-21, miR-34a, miR-150, and miR-155 on HSPCs treated and not with 400 μg MM-derived EVs (the higher dose). (B) The target genes of hsa-miRNAs were analyzed by the bioinformatics tool miRTargetLink human. The central node represents miR-21, miR-34a, miR-150, and miR-155, and it was surrounded by the validated target with strong evidence. The bar graphs represent the average of three replicates. (C) The table showed miR-21, miR-150, and miR-155 amount as copies/μl of dPCR reaction mix and copies/ng of EV-RNA in EVs. MM, multiple myeloma; EVs, Extracellular vesicles; HSPC, hematopoietic stem and progenitor cells.