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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Cancer Discov. 2021 Dec 1;11(12):3142–3157. doi: 10.1158/2159-8290.CD-20-0833

Figure 2. LGR6 is prominently expressed by human NK cells.

Figure 2.

(A) The expression of LGR4, LGR5, LGR6 in the single-cell RNA-seq dataset of human melanoma reported previously accessed from Broad Institute’s Single Cell Portal. (B) Visualization of LGR4, LGR5, LGR6, and NCAM1 expression in human immune cell subtypes in DICE datasets. (C) Heatmap visualization of the gene expression levels of LGR4, LGR5, and LGR6 in bulk RNA-seq dataset of human circulating NK cell subsets reported previously. (D) Quantitative RT-PCR analysis of LGR4 expression for different immune cell types isolated from human peripheral blood pooled by two different donors. (E) Protein expression of LGR4 in different immune cell types isolated from human peripheral blood from two different donors. (F) Quantitative RT-PCR analysis of LGR6 expression for different immune cell types isolated from human peripheral blood pooled by two different donors. (G) Protein expression of LGR6 in different immune cell types isolated from human peripheral blood from two different donors. (H) Spearman’s rank correlation plot for RSPO3 with LGR6 using TCGA SKCM dataset. Data are shown as mean ± s.d. for panels D and F.