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. 2021 Dec 16;12:719432. doi: 10.3389/fimmu.2021.719432

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Copyright © 2021 Nissen, Ryding, Nilsson, Madsen, Olsen, Halekoh, Lydolph, Illes and Blaabjerg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CSF-Neurofilament light chain (NfL) levels at diagnosis and follow-up. CSF-NfL levels at diagnosis were higher in LGI1 patients than in patients with idiopathic/teratoma associated NMDAR-AE (A). In addition, LGI1-AE patients more often presented elevated NfL levels at diagnosis, when using age-adjusted cut-off levels of CSF-NfL (B). Twelve NMDAR-AE (out of 27) (C) and nine LGI1-AE patients (out of 16) (D) had follow-up NfL measurements available. Idiopathic/teratoma associated NMDAR-AE patients CSF-NfL levels decreased over time in majority of cases (C). In contrast, LGI1-AE patients CSF-NfL levels were more heterogenous during follow-up (D). Idiopathic/teratoma associated NMDAR-AE patients with teratomas are shown as green datapoints (A, C). *p value < 0.05, ****p value < 0.0001.