TABLE 3.
Studies with prediction of FVH for uncertain functional outcome.
| Author/Year | No. of patients | Mean Age (year) (range) | Conclusion |
| Li et al. (2021) | 282 | 66.66 ± 11.29 | In patients with proximal MCA occlusion or stenosis ≥70%, a high FVH score represented severe clinical impairment and poor clinical outcomes In acute ischemic stroke patients with proximal MCA occlusion, a high FVH score represented favorable clinical outcomes |
| Zhou et al. (2020a) | 3,577 | NA | FVHs were not associated with functional outcome overall, but were significantly associated with better outcome in those receiving endovascular therapy |
| Jiang et al. (2019) | 37 | 69.41 ± 12.51 | The good functional outcome group had a higher FVH1 (before therapy) score and a lower FVH2 (after therapy) score than the poor functional outcome group |
| Shang et al. (2019) | 459 | NA | FVH is associated with unfavorable outcome within 6 h to 14 days of onset, while the wider distribution of distal FLAIR vascular hyperintensity may be favorable beyond 14 days of onset in MCA infarction |
| Kim et al. (2019) | 112 | 67 (54–79) | For acute stroke patients who do not receive reperfusion therapy, prominent FVH may be independent predictors of an unfavorable outcome In the reperfusion therapy group, there was no association between prominent FVH and the clinical outcome |
| Li et al. (2018) | 38 | 62.52 ± 13.61 | FVH score showed no correlation with 90-day functional clinical outcome and was not sufficient as an independent predictor of short-term clinical outcome |
| Kim et al. (2016) | 87 | FVH(−): 70 (61.7–77.0) FVH(+): 71.5 (58.0–76.0) |
FVH are associated with relatively severe clinical presentation and non-favorable prognosis in patients with cortical borderzone infarcts, but not in patients with internal borderzone infarcts |
| Liu et al. (2016) | 101 | 66.2 ± 17.8 | Higher FVH-ASPECTS measured outside the DWI lesion is associated with good clinical outcomes FVH-ASPECTS measured inside the DWI lesion was predictive of hemorrhagic transformation |
| Sakuta et al. (2016) | 118 | 76 ± 9.7 | Decrease of FVH after t-PA therapy predicts good outcome in patients receiving |
FVH, FLAIR vascular hyperintensity; MCA, middle cerebral artery; ASPECTS, alberta stroke program early computerized tomography score; NA, not available.