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. 2021 Dec 16;8:719866. doi: 10.3389/fmolb.2021.719866

TABLE 2.

The Reference intervals partitioned by each day and sex for 35 MS/MS NBS biomarkers (μM).

Analyte Age Amino acids
Male Female
Lower limit (2.5th) and 90% CI Upper limit (97.5th) and 90% CI No. of samples Lower limit (2.5th) and 90% CI Upper limit (97.5th) and 90% CI No. of samples
ALA 0 to ≤1 day ( a ) 171.0 (168.7–172.8) 404.2 (402.1–406.4) 10,291 171.8 (169.5–173.9) 406.7 (404.3–409.2) 9,540
1 day to ≤2 days ( b ) 163.6 (163.0–166.3) 435.9 (435.2–436.8) 115,292 168.5 (167.8–169.0) 448.4 (447.3–449.4) 105,039
2 days to ≤3 days ( c ) 178.0 (177.8–181.3) 495.8 (495.4–496.1) 1,053,952 185.0 (184.8–185.2) 510.5 (510.1–510.9) 965,270
3 days to ≤4 days ( d ) 188.2 (188.0–191.5) 527.4 (527.0–527.8) 801,271 195.9 (195.6–196.2) 545.3 (544.8–545.8) 729,980
4 days to ≤5 days (e) 188.1 (187.6–192.7) 519.6 (518.6–520.4) 158,961 197.3 (196.6–197.9) 539.1 (538.1–540.3) 143,970
5 days to ≤6 days ( f ) 188.0 (187.1–192.8) 508.0 (506.7–509.1) 96,903 197.1 (196.3–198.0) 526.2 (525.0–527.4) 87,591
6 days to ≤7 days ( g ) 184.1 (183.2–189.9) 496.2 (494.9–497.5) 59,713 195.2 (194.1–196.1) 511.5 (510.2–513.3) 53,406
7 days to ≤8 days ( h ) 182.3 (180.8–186.7) 488.0 (485.8–489.8) 33,973 190.4 (189.1–192.0) 503.6 (501.7–505.8) 29,789
8 days to ≤9 days ( i ) 180.0 (179.0–185.2) 482.1 (479.7–484.3) 25,407 190.2 (188.3–191.8) 495.9 (492.9–497.9) 22,233
9 days to ≤10 days ( j ) 178.3 (177.0–183.4) 479.5 (477.4–481.9) 19,866 189.1 (187.7–190.8) 492.5 (489.7–494.8) 17,364
10 days to ≤11 days ( k ) 178.5 (176.5–184.1) 473.0 (470.2–475.9) 15,363 189.6 (187.9–191.2) 488.7 (486.6–491.9) 13,365
11 days to ≤12 days ( L ) 178.4 (176.5–182.9) 466.9 (464.5–470.1) 14,117 187.0 (184.9–188.4) 479.8 (477.1–481.9) 12,293
12 days to ≤13 days ( lm ) 176.6 (174.8–182.2) 464.9 (462.5–467.9) 12,489 186.3 (184.4–188.4) 471.0 (468.0–473.3) 11,147
13 days to ≤14 days ( m ) 176.4 (174.6–182.0) 466.3 (464.7–468.7) 11,465 186.1 (184.0–188.0) 467.5 (465.1–471.1) 10,117
ARG 0 to ≤1 day ( a ) 1.5 (1.5–1.6) 21.3 (21.0–21.5) 10,355 1.5 (1.4–1.5) 19.4 (19.2–19.7) 9,613
1 day to ≤2 days ( a ) 1.4 (1.4–1.4) 23.8 (23.7–23.9) 116,704 1.4 (1.4–1.4) 22.5 (22.4–22.6) 105,982
2 days to ≤3 days ( b ) 1.5 (1.5–1.5) 25.4 (25.3–25.4) 1,062,374 1.5 (1.5–1.5) 23.8 (23.8–23.8) 971,780
3 days to ≤4 days ( c ) 1.7 (1.7–1.7) 28.0 (28.0–28.0) 806,759 1.6 (1.6–1.6) 26.8 (26.7–26.8) 734,811
4 days to ≤5 days ( def ) 1.7 (1.7–1.7) 30.7 (30.7–30.8) 159,837 1.6 (1.6–1.6) 29.8 (29.7–29.9) 144,722
5 days to ≤6 days ( d ) 1.7 (1.6–1.7) 30.9 (30.8–31.0) 97,358 1.6 (1.6–1.6) 29.3 (29.2–29.5) 87,942
6 days to ≤7 days ( e ) 1.6 (1.6–1.6) 30.9 (30.7–31.0) 60,025 1.6 (1.6–1.6) 29.2 (29.0–29.3) 53,625
7 days to ≤8 days ( f ) 1.6 (1.6–1.6) 31.1 (30.8–31.2) 34,169 1.5 (1.5–1.6) 29.3 (29.1–29.6) 29,956
8 days to ≤9 days ( g ) 1.6 (1.6–1.6) 32.3 (32.1–32.5) 25,571 1.6 (1.6–1.6) 30.5 (30.3–30.8) 22,326
9 days to ≤10 days ( h ) 1.7 (1.7–1.8) 33.3 (33.1–33.6) 19,992 1.7 (1.6–1.7) 31.6 (31.3–31.8) 17,453
10 days to ≤11 days ( i ) 1.9 (1.8–1.9) 34.9 (34.5–35.2) 15,431 1.9 (1.8–1.9) 33.1 (32.8–33.4) 13,398
11 days to ≤12 days ( j ) 2.1 (2.0–2.1) 37.3 (37.0–37.7) 14,169 1.9 (1.9–2.0) 34.3 (34.0–34.6) 12,333
12 days to ≤13 days ( k ) 2.2 (2.2–2.3) 38.3 (37.8–38.6) 12,545 2.0 (2.0–2.1) 35.8 (35.5–36.2) 11,181
13 days to ≤14Vdays ( L ) 2.1 (2.1–2.2) 39.6 (39.2–40.0) 11,513 2.2 (2.1–2.3) 37.3 (36.9–37.6) 10,146
CIT 0 to ≤1 day ( a ) 7.8 (7.7–7.9) 20.0 (19.9–20.2) 10,250 7.9 (7.9–8.0) 20.0 (19.8–20.1) 9,535
1 day to ≤2 days ( a ) 7.5 (7.4–7.5) 20.3 (20.2–20.3) 115,213 7.6 (7.6–7.7) 20.7 (20.7–20.8) 104,802
2 days to ≤3 days ( b ) 7.6 (7.6–7.6) 21.3 (21.3–21.3) 1,048,453 7.9 (7.9–8.0) 22.0 (22.0–22.0) 959,730
3 days to ≤4 days ( c ) 7.8 (7.7–7.8) 21.2 (21.2–21.2) 797,190 8.1 (8.1–8.1) 22.1 (22.1–22.1) 726,262
4 days to ≤5 days ( d ) 7.6 (7.6–7.6) 20.5 (20.4–20.5) 157,824 8.0 (8.0–8.0) 21.4 (21.4–21.4) 143,092
5 days to ≤6 days ( e ) 7.7 (7.6–7.7) 20.6 (20.5–20.6) 96,245 8.0 (8.0–8.0) 21.4 (21.4–21.5) 86,916
6 days to ≤7 days ( b ) 7.6 (7.5–7.6) 21.0 (21.0–21.1) 59,179 8.0 (7.9–8.0) 21.7 (21.6–21.8) 52,850
7 days to ≤8 days ( f ) 7.6 (7.5–7.7) 21.7 (21.6–21.7) 33,642 7.9 (7.8–7.9) 22.4 (22.3–22.5) 29,458
8 days to ≤9 days ( g ) 7.6 (7.5–7.7) 22.5 (22.4–22.6) 25,126 8.0 (8.0–8.1) 23.2 (23.1–23.3) 21,940
9 days to ≤10 days ( h ) 7.9 (7.8–9.0) 23.3 (23.2–23.5) 19,643 8.3 (8.2–8.3) 23.9 (23.7–24.0) 17,187
10 days to ≤11 days ( i ) 8.1 (8.0–8.2) 24.0 (23.8–24.1) 15,175 8.4 (8.3–8.5) 24.8 (24.7–25.0) 13,189
11 days to ≤12 days ( j ) 8.7 (8.6–8.9) 24.5 (24.3–24.7) 13,972 8.6 (8.4–8.7) 25.0 (24.9–25.2) 12,105
12 days to ≤13 days ( k ) 8.6 (8.4–8.7) 24.9 (24.8–25.1) 12,342 9.0 (8.9–9.1) 25.5 (25.3–25.8) 10,995
13 days to ≤14 days ( L ) 8.7 (8.6–8.8) 25.3 (25.1–25.5) 11,379 9.0 (8.9–9.1) 26.1 (26.0–26.3) 9,951
GLY 0 to ≤1 day ( a ) 310.4 (306.9–316.7) 682.4 (679.4–684.9) 10,321 317.1 (313.1–320.2) 691.6 (688.3–694.8) 9,587
1 day to ≤2 days ( b ) 289.6 (288.5–295.6) 738.1 (736.7–739.4) 115,855 301.7 (300.8–302.8) 753.6 (751.8–755.2) 105,328
2 days to ≤3 days ( c ) 287.1 (286.8–292.4) 766.7 (766.2–767.2) 1,052,604 299.4 (299.0–299.7) 777.6 (777.0–778.2) 963,360
3 days to ≤4 days ( d ) 273.0 (272.7–279.4) 737.1 (736.5–737.6) 799,784 286.3 (285.9–286.6) 751.5 (750.9–752.0) 729,189
4 days to ≤5 days ( e ) 238.1 (237.4–243.9) 630.8 (629.7–631.8) 158,084 250.0 (249.3–250.7) 646.3 (645.2–647.6) 143,631
5 days to ≤6 days ( f ) 222.9 (222.1–227.8) 580.3 (579.0–581.4) 95,506 232.2 (231.3–233.0) 592.8 (591.4–594.6) 86,842
6 days to ≤7 days ( g ) 213.4 (212.4–217.3) 550.0 (548.5–551.8) 58,328 222.5 (221.5–223.6) 566.8 (565.5–568.6) 52,592
7 days to ≤8 days ( h ) 211.0 (210.0–214.0) 538.8 (537.0–541.0) 33,096 218.4 (217.3–219.8) 554.7 (552.7–557.3) 29,265
8 days to ≤9 days ( i ) 207.5 (205.5–212.1) 524.5 (522.4–526.7) 24,687 216.7 (215.3–218.4) 536.4 (534.2–539.1) 21,780
9 days to ≤10 days ( j ) 207.8 (206.3–211.5) 513.4 (511.6–516.3) 19,284 213.7 (211.9–215.4) 526.2 (523.7–528.0) 16,971
10 days to ≤11 days ( k ) 204.1 (202.3–208.1) 506.5 (503.9–509.2) 14,784 212.6 (210.6–214.1) 515.2 (513.2–518.9) 13,016
11 days to ≤12 days ( L ) 201.0 (199.1–204.2) 487.7 (483.8–490.6) 13,520 206.3 (204.0–208.1) 494.8 (492.4–497.3) 11,882
12 days to ≤13 days ( L ) 201.9 (200.4–205.8) 484.2 (481.6–486.2) 11,973 207.9 (206.2–210.7) 494.4 (491.2–497.8) 10,764
13 days to ≤14 days ( m ) 198.7 (197.4–201.8) 479.3 (477.0–481.5) 10,879 204.7 (203.2–206.5) 482.0 (478.9–484.9) 9,688
LEU/ILE/ALLO-ILE/PRO-OH 0 to ≤1 day ( a ) 61.2 (60.8–61.9) 195.0 (193.5–196.1) 16,934 61.2 (60.8–61.9) 195.0 (193.5–196.1) 16,934
1 day to ≤2 days ( b ) 76.0 (75.6–76.2) 210.5 (210.1–210.9) 113,894 76.8 (76.5–77.1) 214.8 (214.3–215.3) 103,619
2 days to ≤3 days ( c ) 92.0 (91.9–93.1) 229.4 (229.3–229.6) 1,055,947 94.5 (94.4–94.6) 234.7 (234.5–234.9) 966,309
3 days to ≤4 days ( d ) 98.2 (98.1–99.4) 245.7 (245.5–245.9) 801,425 101.3 (101.2–101.4) 250.9 (250.7–251.1) 729,610
4 days to ≤5 days ( e ) 97.6 (97.3–98.9) 257.6 (257.2–258.1) 158,196 100.2 (99.8–100.5) 262.2 (261.7–262.7) 143,037
5 days to ≤6 days ( f ) 99.0 (98.6–100.4) 268.8 (268.2–269.4) 96,026 101.9 (101.5–102.2) 274.0 (273.5–274.7) 86,576
6 days to ≤7 days ( g ) 98.3 (97.8–100.7) 273.5 (272.6–274.3) 59,038 101.7 (101.1–102.4) 278.2 (277.5–279.1) 52,609
7 days to ≤8 days ( h ) 100.2 (99.4–102.0) 277.6 (276.7–278.6) 33,575 102.5 (101.6–103.3) 282.0 (281.0–283.3) 29,328
8 days to ≤9 days ( i ) 100.4 (99.7–102.2) 277.5 (276.2–278.6) 25,098 103.6 (103.0–104.2) 284.4 (282.8–285.9) 21,809
9days to ≤10 days ( ij ) 100.4 (99.7–103.2) 277.3 (276.1–278.4) 19,623 104.9 (104.0–105.9) 282.7 (281.4–284.2) 17,052
10 days to ≤11 days ( ij ) 101.3 (100.5–103.5) 276.6 (274.9–278.0) 15,166 105.1 (103.7–105.9) 284.2 (282.8–285.7) 13,113
11 days to ≤12 days ( ik ) 101.5 (100.4–103.8) 273.6 (272.0–274.6) 13,970 105.2 (104.0–106.8) 282.0 (280.3–283.1) 12,100
12 days to ≤13 days ( jk ) 100.3 (99.3–103.3) 275.5 (274.0–277.3) 12,372 106.3 (105.2–107.4) 281.2 (279.4–282.2) 10,959
13 days to ≤14 days ( k ) 102.5 (100.9–105.8) 274.2 (272.2–275.7) 11,362 104.6 (102.7–105.5) 281.8 (279.9–283.0) 9,966
MET 0 to ≤1 day ( a ) 11.7 (11.6–11.8) 31.0 (30.8–31.1) 19,894 11.7 (11.6–11.8) 31.0 (30.8–31.1) 19,894
1 day to ≤2 days ( b ) 10.5 (10.4–10.5) 31.0 (31.0–31.1) 116,118 10.8 (10.7–10.9) 32.4 (32.3–32.5) 105,323
2 days to ≤3 days ( c ) 9.0 (9.0–9.0) 30.5 (30.5–30.5) 1,054,481 9.5 (9.5–9.5) 31.8 (31.8–31.8) 965,052
3 days to ≤4 days ( d ) 9.0 (9.0–9.0) 31.3 (31.3–31.3) 800,415 9.6 (9.6–9.6) 32.7 (32.7–32.8) 729,270
4 days to ≤5 days ( e ) 8.7 (8.7–8.8) 30.5 (30.4–30.6) 158,368 9.2 (9.1–9.2) 31.8 (31.7–31.9) 143,444
5 days to ≤6 days ( f ) 8.5 (8.5–8.6) 29.9 (29.9–30.0) 96,333 9.0 (9.0–9.0) 31.1 (31.0–31.1) 87,247
6 days to ≤7 days ( g ) 8.7 (8.6–8.7) 30.0 (29.9–30.1) 59,410 9.0 (8.9–9.0) 30.8 (30.7–30.9) 53,126
7 days to ≤8 days ( d ) 8.9 (8.9–9.0) 30.7 (30.6–30.9) 33,839 9.2 (9.1–9.3) 31.3 (31.2–31.5) 29,756
8 days to ≤9 days ( h ) 9.0 (8.9–9.1) 31.4 (31.3–31.6) 25,370 9.6 (9.5–9.7) 32.2 (32.0–32.4) 22,141
9 days to ≤10 days ( i ) 9.3 (9.2–9.5) 32.4 (32.2–32.5) 19,833 9.7 (9.5–9.9) 33.0 (32.9–33.2) 17,301
10 days to ≤11 days ( j ) 9.5 (9.4–9.7) 33.3 (33.1–33.6) 15,292 9.8 (9.7–10.0) 33.7 (33.4–33.9) 13,286
11 days to ≤12 days ( a ) 9.9 (9.9–10.1) 33.5 (33.2–33.7) 14,085 9.9 (9.8–10.1) 34.2 (34.0–34.5) 12,208
12 days to ≤13 days ( k ) 10.0 (9.8–10.1) 34.2 (34.0–34.4) 12,442 10.2 (10.0–10.4) 34.8 (34.5–35.1) 11,069
13 days to ≤14 days ( L ) 10.0 (9.9–10.2) 34.9 (34.6–35.1) 11,418 10.5 (10.3–10.6) 35.2 (34.9–35.4) 10,050
ORN 0 to ≤1 day ( a ) 42.9 (42.4–43.2) 149.6 (147.9–150.4) 9,480 43.3 (42.9–43.9) 145.0 (143.8–145.8) 8,768
1 day to ≤2 days ( b ) 50.0 (49.9–49.3) 169.7 (169.3–170.2) 112,878 49.6 (49.4–49.7) 169.0 (168.7–169.4) 102,396
2 days to ≤3 days ( c ) 61.1 (61.0–61.1) 205.3 (205.2–205.5) 1,049,193 61.7 (61.7–61.8) 202.0 (201.9–202.2) 961,443
3 days to ≤4 days ( d ) 67.2 (67.1–67.3) 219.4 (219.2–219.5) 798,075 68.5 (68.4–68.6) 218.1 (217.9–218.3) 728,161
4 days to ≤5 days ( e ) 66.2 (65.9–66.4) 212.1 (211.7–212.5) 158,479 67.3 (67.0–67.5) 212.3 (211.8–212.6) 143,683
5 days to ≤6 days ( f ) 64.2 (63.9–65.5) 208.7 (208.3–209.3) 96,493 65.6 (65.3–65.9) 207.5 (207.0–208.1) 87,300
6 days to ≤7 days ( g ) 61.8 (61.5–62.3) 200.6 (200.0–201.1) 59,402 63.0 (62.6–63.4) 200.4 (199.8–201.1) 53,184
7 days to ≤8 days ( h ) 61.4 (60.8–62.9) 198.0 (197.2–199.0) 33,810 61.9 (61.4–62.5) 196.2 (195.5–197.0) 29,639
8 days to ≤9 days ( chi ) 61.8 (61.2–62.2) 196.7 (196.2–197.4) 47,369 61.8 (61.2–62.2) 196.7 (196.2–197.4) 47,369
9 days to ≤10 days ( i ) 63.0 (62.4–63.3) 195.8 (195.2–196.5) 37,062 63.0 (62.4–63.3) 195.8 (195.2–196.5) 37,062
10 days to ≤11 days ( gk ) 63.8 (63.4–64.4) 198.6 (197.6–199.5) 28,618 63.8 (63.4–64.4) 198.6 (197.6–199.5) 28,618
11 days to ≤12 days ( k ) 64.1 (63.3–64.9) 199.4 (198.4–200.2) 14,093 64.1 (63.1–64.9) 195.2 (194.0–196.3) 12,229
12 days to ≤13 days ( f ) 66.5 (65.9–67.2) 200.4 (199.5–201.8) 23,587 66.5 (65.9–67.2) 200.4 (199.5–201.8) 23,587
13 days to ≤14 days ( f ) 67.5 (67.0–68.0) 200.0 (199.0–200.8) 21,545 67.5 (67.0–68.0) 200.0 (199.0–200.8) 21,545
PEH 0 to ≤1 day ( a ) 37.3 (37.0–37.6) 75.3 (74.8–75.7) 10,289 36.6 (36.3–37.0) 73.6 (73.2–74.0) 9,566
1 day to ≤2 days ( b ) 34.7 (34.7–34.8) 74.2 (74.1–74.3) 221,146 34.7 (34.7–34.8) 74.2 (74.1–74.3) 221,146
2 days to ≤3 days ( c ) 35.4 (35.3–35.4) 78.5 (78.4–78.5) 1,053,903 35.5 (35.4–35.5) 78.9 (78.8–78.9) 963,641
3 days to ≤4 days ( a ) 34.8 (34.8–34.8) 78.0 (78.0–78.1) 799,887 34.9 (34.9–35.0) 78.2 (78.2–78.3) 728,624
4 days to ≤5 days ( d ) 32.0 (31.9–32.1) 73.2 (73.1–73.4) 157,689 32.1 (32.0–32.2) 73.6 (73.5–73.7) 142,792
5 days to ≤6 days ( e ) 31.1 (31.0–31.2) 72.7 (72.6–72.9) 95,700 31.4 (31.3–31.5) 72.6 (72.5–72.8) 86,626
6 days to ≤7 days ( f ) 30.4 (30.2–30.5) 71.9 (71.8–72.2) 58,792 30.7 (30.6–30.9) 71.9 (71.7–72.1) 52,598
7 days to ≤8 days ( g ) 30.0 (29.8–30.1) 71.5 (71.2–71.8) 33,366 30.1 (29.9–30.3) 72.3 (72.1–72.6) 29,279
8 days to ≤9 days ( h ) 29.6 (29.5–30.9) 71.1 (70.9–71.3) 24,907 30.3 (29.9–30.5) 72.1 (71.8–72.3) 21,833
9 days to ≤10 days ( i ) 29.6 (29.3–30.8) 70.9 (70.6–71.2) 19,481 30.1 (29.8–30.3) 72.0 (71.8–72.4) 17,056
10 days to ≤11 days ( j ) 29.4 (29.1–29.7) 69.1 (68.7–69.4) 15,017 29.8 (29.5–30.1) 70.6 (70.3–70.9) 13,080
11 days to ≤12 days ( k ) 29.3 (29.1–29.5) 68.6 (68.4–68.9) 13,807 30.0 (29.8–30.4) 69.5 (69.1–69.8) 12,052
12 days to ≤13 days ( L ) 29.3 (29.0–29.6) 68.1 (67.8–68.5) 12,221 30.1 (29.8–30.4) 70.1 (69.7–70.5) 10,939
13 days to ≤14 days ( m ) 29.2 (28.7–29.4) 67.7 (67.3–68.0) 11,218 30.3 (29.9–30.5) 68.7 (68.3–69.1) 9,947
PRO 0 to ≤1 day ( a ) 109.2 (108.3–108.2) 237.0 (235.6–238.7) 10,251 107.4 (106.6–108.4) 231.7 (230.3–233.2) 9,471
1 day to ≤2 days ( b ) 109.8 (109.5–110.2) 262.6 (262.1–263.2) 115,138 110.6 (110.3–111.0) 264.1 (263.6–264.6) 104,636
2 days to ≤3 days ( c ) 120.3 (120.2–121.5) 294.2 (294.0–294.4) 1,052,842 122.3 (122.2–122.4) 295.2 (295.0–295.4) 963,922
3 days to ≤4 days ( d ) 125.3 (125.1–126.4) 310.4 (310.1–310.6) 797,965 127.6 (127.4–127.8) 312.6 (312.3–312.8) 727,183
4 days to ≤5 days ( e ) 119.7 (119.4–121.1) 310.7 (310.1–311.2) 157,703 122.1 (121.8–122.3) 314.3 (313.7–314.8) 143,055
5 days to ≤6 days ( f ) 118.5 (117.9–120.9) 316.5 (315.8–317.1) 96,029 121.4 (120.9–121.9) 320.6 (319.8–321.4) 86,822
6 days to ≤7 days ( f ) 117.0 (116.3–119.5) 316.1 (315.2–317.2) 59,148 121.7 (121.1–122.3) 319.1 (318.2–319.9) 52,980
7 days to ≤8 days ( g ) 117.4 (116.7–119.1) 313.8 (312.5–315.0) 33,731 120.7 (119.9–121.3) 316.0 (314.9–317.5) 29,599
8 days to ≤9 days ( eh ) 116.8 (116.1–118.7) 306.8 (305.1–308.3) 25,231 120.0 (119.1–121.1) 314.4 (313.2–315.9) 22,058
9 days to ≤10 days ( hi ) 116.2 (114.8–119.0) 306.2 (304.9–307.4) 19,744 121.8 (120.9–122.9) 310.3 (308.7–312.1) 17,283
10 days to ≤11 days ( ij ) 116.7 (115.8–119.9) 302.1 (300.1–303.5) 15,237 120.5 (118.8–121.4) 305.7 (304.1–307.3) 13,279
11 days to ≤12 days ( jk ) 117.9 (116.8–119.4) 300.2 (298.5–301.7) 14,052 121.3 (120.2–122.7) 303.4 (301.7–305.1) 12,240
12 days to ≤13 days ( k ) 117.8 (116.8–119.8) 299.1 (297.2–300.8) 12,432 120.6 (119.8–121.6) 298.6 (297.3–300.1) 11,100
13 days to ≤14 days ( k ) 117.6 (116.2–119.3) 295.9 (294.3–297.6) 11,413 120.0 (118.6–121.8) 295.7 (293.0–297.8) 10,081
TYR 0 to ≤1 day ( a ) 45.5 (45.0–45.1) 152.5 (151.4–153.7) 10,244 45.0 (44.4–45.8) 150.6 (149.2–152.0) 9,485
1 day to ≤2 days ( b ) 45.6 (45.4–45.7) 162.4 (162.1–162.7) 219,700 45.6 (45.4–45.7) 162.4 (162.1–162.7) 219,700
2 days to ≤3 days ( c ) 49.7 (49.6–50.7) 176.6 (176.4–176.7) 1,050,528 50.7 (50.6–50.8) 177.6 (177.5–177.7) 962,728
3 days to ≤4 days ( d ) 52.9 (52.8–53.0) 189.1 (188.9–189.2) 797,519 54.5 (54.4–54.6) 193.5 (193.3–193.7) 727,587
4 days to ≤5 days ( e ) 50.4 (50.2–51.7) 190.4 (189.9–190.8) 157,698 52.4 (52.2–52.7) 198.2 (197.8–198.6) 142,924
5 days to ≤6 days ( f ) 48.6 (48.3–50.0) 188.1 (187.6–188.5) 95,962 50.6 (50.2–50.8) 196.0 (195.4–196.5) 86,967
6 days to ≤7 days ( g ) 46.5 (46.1–47.9) 181.5 (181.0–182.1) 59,135 48.8 (48.5–49.3) 188.0 (187.4–188.6) 52,983
7 days to ≤8 days ( h ) 45.0 (44.5–46.4) 172.3 (171.5–172.9) 33,698 47.8 (47.4–48.6) 180.2 (179.3–181.2) 29,630
8 days to ≤9 days ( i ) 44.8 (44.4–46.2) 166.7 (166.2–167.6) 25,164 47.6 (47.1–48.1) 173.2 (172.7–174.2) 22,130
9 days to ≤10 days ( j ) 45.0 (44.4–46.6) 159.6 (158.4–160.5) 19,724 48.4 (47.9–49.1) 167.9 (167.0–168.7) 17,298
10 days to ≤11 days ( jk ) 45.0 (44.2–46.6) 157.4 (156.0–158.6) 15,256 48.2 (47.3–49.1) 166.5 (165.2–167.7) 13,301
11 days to ≤12 days ( k ) 46.1 (45.7–47.9) 154.9 (154.1–156.0) 14,046 49.0 (47.9–49.9) 164.9 (163.9–166.6) 12,242
12 days to ≤13 days ( j ) 45.9 (45.2–47.9) 152.8 (151.5–153.8) 12,420 49.6 (49.0–50.6) 164.0 (162.9–165.1) 11,112
VAL 13 days to ≤14 days ( j ) 45.8 (45.2–47.5) 152.5 (151.3–153.8) 11,409 49.3 (48.5–50.3) 165.5 (164.3–167.2) 10,070
0 to ≤1 day ( a ) 56.2 (55.9–56.5) 161.1 (160.2–161.8) 17,402 56.2 (55.9–56.5) 161.1 (160.2–161.8) 17,402
1 day to ≤2 days ( b ) 64.9 (64.7–65.2) 179.1 (178.7–179.5) 112,450 66.4 (66.1–66.6) 184.9 (184.4–185.3) 102,614
2 days to ≤3 days ( c ) 79.5 (79.4–80.6) 204.4 (204.3–204.6) 1,051,646 82.4 (82.3–82.5) 211.2 (211.1–211.4) 962,851
3 days to ≤4 days ( d ) 87.4 (87.2–89.5) 214.9 (214.8–215.1) 800,721 91.1 (90.9–91.2) 221.7 (221.5–221.8) 728,786
4 days to ≤5 days ( e ) 87.3 (87.0–88.5) 216.6 (216.2–216.9) 158,645 90.6 (90.3–90.9) 223.7 (223.4–224.2) 143,548
5 days to ≤6 days ( f ) 86.9 (86.6–88.2) 222.8 (222.3–223.3) 96,537 90.8 (90.6–91.2) 230.6 (230.0–231.1) 87,120
6 days to ≤7 days ( f ) 84.1 (83.6–86.4) 225.3 (224.7–225.8) 59,428 88.4 (88.0–88.9) 233.7 (232.8–234.5) 53,058
7 days to ≤8 days ( f ) 84.0 (83.2–86.6) 226.5 (225.8–227.2) 33,775 87.7 (87.1–88.2) 234.4 (233.8–235.1) 29,574
8 days to ≤9 days ( f ) 83.3 (82.5–85.0) 224.8 (224.2–225.9) 25,296 88.3 (87.4–88.8) 235.2 (234.2–236.4) 22,039
9 days to ≤10 days ( f ) 83.0 (82.3–86.9) 225.5 (223.9–226.5) 19,771 88.4 (87.3–89.4) 234.2 (233.4–235.2) 17,232
10 days to ≤11 days ( g ) 83.5 (82.7–85.3) 222.1 (220.8–222.9) 15,300 88.5 (87.5–89.4) 233.3 (231.8–234.6) 13,266
11 days to ≤12 days ( g ) 83.1 (82.1–86.1) 220.9 (219.7–222.7) 14,075 88.5 (87.3–89.6) 232.0 (230.7–233.0) 12,206
12 days to ≤13 days ( fg ) 83.1 (82.4–86.4) 222.5 (220.9–223.9) 12,453 88.8 (87.8–90.0) 234.1 (232.3–235.8) 11,089
13 days to ≤14 days ( g ) 83.5 (82.7–85.3) 220.5 (219.0–222.2) 11,422 88.9 (87.7–90.2) 231.8 (230.8–233.5) 10,063
Acylcarnitines
C0 0 to ≤1 day ( a ) 10.44 (10.30–10.61) 33.08 (32.85–33.38) 10,290 10.14 (10.03–10.29) 29.97 (29.73–30.26) 9,518
1 day to ≤2 days ( b ) 10.30 (10.27–10.35) 34.70 (34.62–34.78) 115,510 9.75 (9.71–9.80) 31.88 (31.80–31.97) 104,661
2 days to ≤3 days ( c ) 11.30 (11.28–10.31) 37.73 (37.70–37.76) 1,053,208 10.65 (10.64–10.66) 34.69 (34.66–34.71) 964,639
3 days to ≤4 days ( d ) 11.88 (11.86–11.90) 38.59 (38.55–38.62) 800,275 11.09 (11.07–11.11) 35.64 (35.60–35.67) 730,370
4 days to ≤5 days ( d ) 11.86 (11.81–11.90) 38.23 (38.15–38.30) 158,847 11.05 (11.01–11.09) 35.71 (35.64–35.77) 143,909
5 days to ≤6 days ( e ) 11.84 (11.78–11.90) 38.62 (38.53–38.68) 96,681 11.20 (11.12–11.26) 36.37 (36.29–36.47) 87,461
6 days to ≤7 days ( f ) 11.76 (11.70–11.90) 38.68 (38.53–38.80) 59,617 11.22 (11.13–11.28) 36.42 (36.31–36.51) 53,315
7 days to ≤8 days ( g ) 11.78 (11.70–11.91) 39.12 (38.89–39.30) 33,928 11.28 (11.17–11.39) 37.26 (37.10–37.38) 29,758
8 days to ≤9 days ( h ) 12.09 (11.95–11.20) 39.70 (39.54–39.86) 25,400 11.67 (11.56–11.82) 37.88 (37.67–38.11) 22,199
9 days to ≤10 days ( i ) 12.07 (11.91–11.14) 40.35 (40.15–40.59) 19,846 11.52 (11.36–11.64) 38.46 (38.26–38.75) 17,339
10 days to ≤11 days ( j ) 12.14 (11.96–12.29) 40.88 (40.68–41.12) 15,313 11.80 (11.60–11.98) 39.07 (38.87–39.33) 13,330
11 days to ≤12 days ( k ) 12.35 (12.19–12.48) 41.02 (40.75–41.22) 14,104 12.15 (11.96–12.31) 39.69 (39.33–39.98) 12,284
12 days to ≤13 days ( L ) 12.71 (12.52–12.89) 41.39 (41.04–41.69) 12,475 12.56 (12.27–12.83) 39.89 (39.66–40.14) 11,122
13 days to ≤14 days ( m ) 12.97 (12.78–13.20) 41.95 (41.71–42.33) 11,464 12.83 (12.65–13.17) 40.46 (40.18–40.77) 10,097
C2 0 to ≤1 day ( a ) 9.38 (9.21–9.53) 31.23 (31.00–31.49) 10,275 8.90 (8.70–9.07) 28.44 (28.17–28.74) 9,550
1 day to ≤2 days ( b ) 9.72 (9.66–9.77) 32.83 (32.77–32.91) 115,029 8.99 (8.93–9.04) 30.43 (30.34–30.51) 105,003
2 days to ≤3 days ( c ) 8.78 (8.75–8.80) 32.74 (32.71–32.76) 1,045,982 8.17 (8.15–8.19) 30.42 (30.40–30.45) 960,681
3 days to ≤4 days ( d ) 8.41 (8.39–8.43) 30.77 (30.75–30.80) 797,123 7.91 (7.89–7.93) 28.87 (28.84–28.90) 727,829
4 days to ≤5 days ( e ) 7.35 (7.30–7.39) 26.91 (26.85–26.97) 158,368 7.00 (6.96–7.02) 25.43 (25.38–25.49) 143,392
5 days to ≤6 days ( f ) 6.61 (6.56–6.67) 24.29 (24.22–24.34) 96,345 6.37 (6.31–6.42) 23.15 (23.09–23.20) 86,967
6 days to ≤7 days ( g ) 5.99 (5.97–5.04) 21.82 (21.77–21.90) 59,143 5.83 (5.77–5.88) 20.89 (20.84–20.95) 52,725
7 days to ≤8 days ( h ) 5.43 (5.34–5.52) 20.25 (20.14–20.32) 33,407 5.31 (5.25–5.37) 19.53 (19.45–19.61) 29,210
8 days to ≤9 days ( i ) 5.06 (5.01–5.12) 19.00 (18.92–19.08) 24,792 5.00 (4.94–5.06) 18.53 (18.41–18.62) 21,616
9 days to ≤10 days ( j ) 4.92 (4.84–5.00) 18.43 (18.32–18.54) 19,295 4.85 (4.78–4.92) 17.50 (17.36–17.60) 16,762
10 days to ≤11 days ( k ) 4.82 (4.73–4.95) 17.67 (17.54–17.80) 14,819 4.70 (4.59–4.75) 17.05 (16.92–17.13) 12,811
11 days to ≤12 days ( L ) 4.79 (4.70–4.85) 17.38 (17.28–17.52) 13,642 4.70 (4.61–4.81) 16.61 (16.49–16.75) 11,785
12 days to ≤13 days ( kl ) 4.92 (4.84–5.03) 17.44 (17.33–17.55) 12,108 4.64 (4.50–4.71) 16.43 (16.26–16.57) 10,674
13 days to ≤14 days ( kl ) 4.96 (4.90–5.06) 17.34 (17.24–17.47) 11,127 4.78 (4.64–4.91) 16.76 (16.65–16.89) 9,741
C3 0 to ≤1 day ( a ) 0.79 (0.78–0.80) 2.82 (2.80–2.84) 10,304 0.77 (0.76–0.79) 2.66 (2.63–2.67) 9,551
1 day to ≤2 days ( a ) 0.78 (0.78–0.78) 2.88 (2.88–2.89) 115,866 0.74 (0.73–0.74) 2.75 (2.75–2.76) 105,326
2 days to ≤3 days ( b ) 0.77 (0.77–0.77) 2.95 (2.95–2.95) 1,052,696 0.74 (0.74–0.74) 2.84 (2.83–2.84) 964,210
3 days to ≤4 days ( c ) 0.75 (0.75–0.76) 2.78 (2.78–2.78) 801,609 0.72 (0.72–0.72) 2.70 (2.70–2.70) 730,749
4 days to ≤5 days ( d ) 0.66 (0.66–0.66) 2.44 (2.44–2.45) 159,178 0.64 (0.64–0.65) 2.37 (2.36–2.37) 143,979
5 days to ≤6 days ( e ) 0.57 (0.57–0.57) 2.12 (2.11–2.13) 96,549 0.55 (0.54–0.55) 2.09 (2.09–2.10) 87,072
6 days to ≤7 days ( f ) 0.49 (0.48–0.49) 1.88 (1.87–1.88) 58,757 0.48 (0.48–0.49) 1.86 (1.85–1.86) 52,232
7 days to ≤8 days ( g ) 0.45 (0.45–0.46) 1.77 (1.77–1.78) 32,929 0.43 (0.42–0.43) 1.75 (1.74–1.76) 28,637
8 days to ≤9 days ( h ) 0.41 (0.41–0.41) 1.68 (1.67–1.68) 45,176 0.41 (0.41–0.41) 1.68 (1.67–1.68) 45,176
9 days to ≤10 days ( i ) 0.39 (0.38–0.39) 1.69 (1.68–1.70) 18,657 0.39 (0.39–0.40) 1.64 (1.62–1.65) 16,211
10 days to ≤11 days ( ij ) 0.38 (0.38–0.39) 1.67 (1.66–1.68) 26,677 0.38 (0.38–0.39) 1.67 (1.66–1.68) 26,677
11 days to ≤12 days ( j ) 0.38 (0.37–0.38) 1.66 (1.65–1.66) 24,589 0.38 (0.37–0.38) 1.66 (1.65–1.66) 24,589
12 days to ≤13 days ( h ) 0.39 (0.39–0.40) 1.71 (1.70–1.72) 22,153 0.39 (0.39–0.40) 1.71 (1.70–1.72) 22,153
13 days to ≤14 days ( k ) 0.39 (0.38–0.39) 1.74 (1.73–1.75) 20,156 0.39 (0.38–0.39) 1.74 (1.73–1.75) 20,156
C3-DC + C4-OH 0 to ≤1 day ( a ) 0.04 (0.03–0.04) 0.20 (0.19–0.20) 10,361 0.04 (0.04–0.04) 0.18 (0.18–0.19) 9,615
1 day to ≤2 days ( b ) 0.04 (0.04–0.04) 0.31 (0.31–0.31) 115,192 0.04 (0.04–0.04) 0.32 (0.32–0.32) 101,951
2 days to ≤3 days ( c ) 0.05 (0.05–0.05) 0.27 (0.27–0.27) 1,052,948 0.04 (0.04–0.04) 0.26 (0.26–0.26) 964,832
3 days to ≤4 days ( d ) 0.04 (0.04–0.04) 0.23 (0.23–0.23) 801,386 0.04 (0.04–0.04) 0.22 (0.22–0.22) 728,632
4 days to ≤5 days ( e ) 0.04 (0.04–0.04) 0.17 (0.17–0.17) 158,869 0.04 (0.04–0.04) 0.17 (0.17–0.17) 144,283
5 days to ≤6 days ( f ) 0.04 (0.04–0.04) 0.15 (0.15–0.15) 96,429 0.04 (0.04–0.04) 0.15 (0.15–0.15) 87,606
6 days to ≤7 days ( g ) 0.04 (0.04–0.04) 0.15 (0.15–0.15) 112,850 0.04 (0.04–0.04) 0.15 (0.15–0.15) 112,850
7 days to ≤8 days ( h ) 0.04 (0.03–0.04) 0.13 (0.13–0.13) 33,775 0.04 (0.04–0.04) 0.13 (0.12–0.13) 29,628
8 days to ≤9 days ( i ) 0.03 (0.03–0.03) 0.13 (0.13–0.13) 47,262 0.03 (0.03–0.03) 0.13 (0.13–0.13) 47,262
9 days to ≤10 days ( j ) 0.03 (0.03–0.03) 0.13 (0.13–0.13) 36,809 0.03 (0.03–0.03) 0.13 (0.13–0.13) 36,809
10 days to ≤11 days ( k ) 0.03 (0.03–0.03) 0.11 (0.11–0.11) 15,189 0.03 (0.03–0.03) 0.11 (0.11–0.11) 13,177
11 days to ≤12 days ( L ) 0.03 (0.03–0.03) 0.11 (0.11–0.11) 26,087 0.03 (0.03–0.03) 0.11 (0.11–0.11) 26,087
12 days to ≤13 days ( m ) 0.03 (0.03–0.03) 0.11 (0.11–0.11) 23,335 0.03 (0.03–0.03) 0.11 (0.11–0.11) 23,335
13 days to ≤14 days ( n ) 0.03 (0.03–0.03) 0.10 (0.10–0.10) 21,301 0.03 (0.03–0.03) 0.10 (0.10–0.10) 21,301
C4 0 to ≤1 day ( a ) 0.11 (0.10–0.11) 0.32 (0.32–0.33) 10,293 0.12 (0.12–0.12) 0.33 (0.33–0.34) 9,560
1 day to ≤2 days ( b ) 0.07 (0.06–0.07) 0.32 (0.32–0.32) 111,519 0.07 (0.07–0.07) 0.33 (0.32–0.33) 100,894
2 days to ≤3 days ( c ) 0.10 (0.10–0.10) 0.33 (0.33–0.33) 1,047,763 0.11 (0.11–0.11) 0.36 (0.36–0.36) 956,213
3 days to ≤4 days ( a ) 0.11 (0.11–0.11) 0.32 (0.32–0.32) 801,056 0.12 (0.12–0.12) 0.34 (0.34–0.34) 728,565
4 days to ≤5 days ( b ) 0.10 (0.10–0.10) 0.30 (0.30–0.30) 158,430 0.11 (0.11–0.11) 0.31 (0.31–0.31) 143,525
5 days to ≤6 days ( d ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 96,413 0.10 (0.10–0.10) 0.30 (0.30–0.30) 87,284
6 days to ≤7 days ( e ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 59,367 0.10 (0.10–0.10) 0.29 (0.29–0.29) 53,174
7 days to ≤8 days ( f ) 0.09 (0.09–0.09) 0.27 (0.27–0.27) 33,637 0.10 (0.10–0.10) 0.28 (0.28–0.28) 29,614
8 days to ≤9 days ( g ) 0.09 (0.09–0.09) 0.27 (0.27–0.27) 25,125 0.09 (0.09–0.09) 0.28 (0.28–0.28) 21,984
9 days to ≤10 days ( h ) 0.09 (0.09–0.09) 0.27 (0.27–0.28) 19,611 0.09 (0.09–0.09) 0.27 (0.27–0.27) 17,173
10 days to ≤11 days ( i ) 0.09 (0.09–0.09) 0.26 (0.26–0.26) 15,141 0.09 (0.09–0.09) 0.27 (0.27–0.27) 13,189
11 days to ≤12 days ( j ) 0.09 (0.09–0.09) 0.26 (0.26–0.26) 13,931 0.09 (0.09–0.09) 0.27 (0.27–0.28) 12,155
12 days to ≤13 days ( k ) 0.09 (0.09–0.09) 0.26 (0.26–0.27) 12,343 0.09 (0.09–0.09) 0.27 (0.27–0.28) 11,034
13 days to ≤14 days ( jk ) 0.09 (0.09–0.09) 0.26 (0.26–0.27) 11,332 0.10 (0.10–0.11) 0.26 (0.25–0.26) 10,025
C4-DC + C5-OH 0 to ≤1 day ( a ) 0.11 (0.11–0.11) 0.29 (0.28–0.29) 10,303 0.10 (0.10–0.10) 0.28 (0.28–0.28) 9,575
1 day to ≤2 days ( b ) 0.06 (0.06–0.06) 0.30 (0.30–0.30) 108,787 0.07 (0.07–0.07) 0.28 (0.28–0.28) 100,757
2 days to ≤3 days ( c ) 0.10 (0.10–0.10) 0.33 (0.33–0.33) 1,049,969 0.10 (0.10–0.10) 0.30 (0.30–0.30) 963,151
3 days to ≤4 days ( d ) 0.11 (0.11–0.11) 0.32 (0.32–0.32) 801,080 0.11 (0.11–0.11) 0.30 (0.30–0.30) 730,521
4 days to ≤5 days ( e ) 0.11 (0.11–0.11) 0.30 (0.30–0.30) 158,757 0.10 (0.10–0.10) 0.28 (0.28–0.28) 143,787
5 days to ≤6 days ( a ) 0.10 (0.10–0.11) 0.30 (0.30–0.30) 96,669 0.10 (0.10–0.10) 0.28 (0.28–0.28) 87,355
6 days to ≤7 days ( f ) 0.10 (0.10–0.10) 0.29 (0.29–0.29) 59,476 0.10 (0.10–0.10) 0.28 (0.28–0.28) 53,122
7 days to ≤8 days ( g ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 33,706 0.10 (0.10–0.10) 0.27 (0.27–0.27) 29,588
8 days to ≤9 days ( g ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 25,164 0.10 (0.10–0.10) 0.27 (0.27–0.27) 21,989
9 days to ≤10 days ( g ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 19,612 0.10 (0.10–0.10) 0.27 (0.27–0.27) 17,152
10 days to ≤11 days ( hi ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 15,168 0.10 (0.10–0.10) 0.27 (0.27–0.27) 13,167
11 days to ≤12 days ( h ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 13,969 0.10 (0.10–0.10) 0.27 (0.27–0.27) 12,134
12 days to ≤13 days ( i ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 12,350 0.10 (0.10–0.10) 0.27 (0.27–0.27) 10,987
13 days to ≤14 days ( hi ) 0.10 (0.10–0.10) 0.28 (0.28–0.28) 11,365 0.10 (0.10–0.10) 0.27 (0.27–0.27) 9,939
C5 0 to ≤1 day ( a ) 0.04 (0.04–0.04) 0.15 (0.15–0.15) 10,356 0.04 (0.03–0.04) 0.15 (0.15–0.15) 9,606
1 day to ≤2 days ( b ) 0.02 (0.02–0.02) 0.17 (0.17–0.17) 219,252 0.02 (0.02–0.02) 0.18 (0.18–0.18) 219,252
2 days to ≤3 days ( c ) 0.05 (0.05–0.05) 0.17 (0.17–0.17) 1,059,324 0.04 (0.04–0.04) 0.18 (0.18–0.18) 968,680
3 days to ≤4 days ( d ) 0.06 (0.06–0.06) 0.17 (0.17–0.17) 804,862 0.06 (0.06–0.06) 0.18 (0.18–0.18) 732,769
4 days to ≤5 days ( e ) 0.06 (0.06–0.06) 0.18 (0.18–0.18) 158,623 0.06 (0.06–0.06) 0.20 (0.20–0.20) 143,687
5 days to ≤6 days ( f ) 0.06 (0.06–0.06) 0.20 (0.20–0.20) 96,317 0.06 (0.06–0.06) 0.21 (0.21–0.21) 86,996
6 days to ≤7 days ( g ) 0.06 (0.06–0.06) 0.22 (0.22–0.22) 59,235 0.06 (0.06–0.06) 0.23 (0.23–0.23) 52,971
7 days to ≤8 days ( h ) 0.06 (0.06–0.06) 0.23 (0.23–0.23) 33,533 0.06 (0.06–0.06) 0.23 (0.23–0.23) 29,408
8 days to ≤9 days ( i ) 0.06 (0.06–0.06) 0.23 (0.23–0.23) 25,025 0.06 (0.06–0.06) 0.25 (0.25–0.25) 21,907
9 days to ≤10 days ( j ) 0.06 (0.06–0.06) 0.25 (0.25–0.25) 19,534 0.06 (0.05–0.06) 0.25 (0.25–0.26) 17,081
10 days to ≤11 days ( k ) 0.06 (0.06–0.06) 0.25 (0.25–0.25) 15,051 0.06 (0.06–0.06) 0.26 (0.26–0.26) 13,089
11 days to ≤12 days ( L ) 0.06 (0.06–0.06) 0.26 (0.26–0.26) 13,795 0.07 (0.07–0.08) 0.26 (0.26–0.26) 12,014
12 days to ≤13 days ( m ) 0.06 (0.06–0.06) 0.26 (0.26–0.26) 12,242 0.07 (0.07–0.08) 0.26 (0.26–0.26) 10,889
13 days to ≤14 days ( n ) 0.06 (0.06–0.06) 0.26 (0.26–0.26) 11,200 0.07 (0.07–0.07) 0.28 (0.28–0.28) 9,884
C5-DC + C6-OH 0 to ≤1 day ( a ) 0.06 (0.06–0.06) 0.19 (0.19–0.19) 10,339 0.06 (0.06–0.06) 0.18 (0.18–0.18) 9,601
1 day to ≤2 days ( b ) 0.06 (0.06–0.06) 0.25 (0.25–0.25) 114,253 0.06 (0.06–0.06) 0.24 (0.24–0.24) 104,304
2 days to ≤3 days ( c ) 0.06 (0.06–0.06) 0.20 (0.20–0.20) 1,055,950 0.06 (0.06–0.06) 0.19 (0.19–0.19) 966,691
3 days to ≤4 days ( d ) 0.06 (0.06–0.06) 0.18 (0.18–0.18) 803,479 0.05 (0.05–0.05) 0.18 (0.18–0.18) 731,895
4 days to ≤5 days ( e ) 0.05 (0.05–0.05) 0.15 (0.15–0.15) 159,126 0.05 (0.05–0.05) 0.15 (0.15–0.15) 144,036
5 days to ≤6 days ( f ) 0.05 (0.05–0.05) 0.14 (0.14–0.14) 96,757 0.05 (0.04–0.05) 0.13 (0.13–0.14) 87,385
6 days to ≤7 days ( g ) 0.04 (0.04–0.04) 0.13 (0.13–0.13) 59,424 0.04 (0.04–0.04) 0.13 (0.13–0.13) 53,039
7 days to ≤8 days ( h ) 0.04 (0.04–0.04) 0.14 (0.14–0.14) 33,691 0.04 (0.04–0.04) 0.14 (0.14–0.14) 29,509
8 days to ≤9 days ( i ) 0.04 (0.04–0.04) 0.12 (0.12–0.13) 25,127 0.04 (0.04–0.04) 0.12 (0.12–0.12) 21,916
9 days to ≤10 days ( j ) 0.04 (0.04–0.04) 0.12 (0.12–0.12) 19,547 0.04 (0.04–0.04) 0.12 (0.12–0.12) 17,068
10 days to ≤11 days ( k ) 0.04 (0.04–0.04) 0.12 (0.12–0.12) 15,112 0.04 (0.04–0.04) 0.12 (0.12–0.12) 13,100
11 days to ≤12 days ( L ) 0.04 (0.04–0.04) 0.12 (0.12–0.12) 13,881 0.04 (0.04–0.04) 0.12 (0.12–0.12) 12,072
12 days to ≤13 days ( L ) 0.04 (0.04–0.04) 0.12 (0.12–0.12) 12,279 0.04 (0.04–0.04) 0.12 (0.12–0.12) 10,905
13 days to ≤14 days ( m ) 0.04 (0.04–0.04) 0.12 (0.12–0.12) 21,154 0.04 (0.04–0.04) 0.12 (0.12–0.12) 21,154
C6 0 to ≤1 day ( a ) 0.02 (0.02–0.02) 0.08 (0.08–0.08) 10,143 0.03 (0.03–0.03) 0.06 (0.06–0.06) 8,010
1 day to ≤2 days ( b ) 0.02 (0.02–0.02) 0.08 (0.08–0.08) 113,352 0.02 (0.02–0.02) 0.08 (0.08–0.08) 104,220
2 days to ≤3 days ( c ) 0.02 (0.02–0.02) 0.08 (0.08–0.08) 1,033,512 0.02 (0.02–0.02) 0.07 (0.07–0.07) 954,201
3 days to ≤4 days ( d ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 793,074 0.02 (0.02–0.02) 0.07 (0.07–0.07) 727,096
4 days to ≤5 days ( e ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 144,606 0.02 (0.02–0.02) 0.05 (0.05–0.05) 132,721
5 days to ≤6 days ( f ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 89,849 0.01 (0.01–0.01) 0.06 (0.06–0.06) 87,561
6 days to ≤7 days ( g ) 0.01 (0.01–0.01) 0.06 (0.06–0.06) 58,977 0.01 (0.01–0.01) 0.06 (0.06–0.06) 53,389
7 days to ≤8 days ( h ) 0.01 (0.01–0.01) 0.06 (0.06–0.06) 33,574 0.01 (0.01–0.01) 0.06 (0.06–0.06) 29,805
8 days to ≤9 days ( i ) 0.01 (0.01–0.01) 0.06 (0.06–0.06) 25,039 0.01 (0.01–0.01) 0.06 (0.06–0.06) 22,213
9 days to ≤10 days ( f ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 18,278 0.01 (0.01–0.01) 0.06 (0.06–0.06) 17,179
10 days to ≤11 days ( k ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 14,161 0.02 (0.02–0.02) 0.05 (0.05–0.05) 12,347
11 days to ≤12 days ( L ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 12,985 0.02 (0.02–0.02) 0.05 (0.05–0.05) 11,326
12 days to ≤13 days ( em ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 11,464 0.02 (0.02–0.02) 0.05 (0.05–0.05) 10,311
13 days to ≤14 days ( m ) 0.02 (0.02–0.02) 0.05 (0.05–0.05) 10,538 0.02 (0.02–0.02) 0.05 (0.05–0.05) 9,339
C6-DC 0 to ≤1 day ( a ) 0.04 (0.04–0.04) 0.16 (0.16–0.17) 10,343 0.04 (0.04–0.04) 0.18 (0.18–0.19) 9,603
1 day to ≤2 days ( b ) 0.04 (0.04–0.05) 0.23 (0.23–0.23) 116,601 0.05 (0.04–0.05) 0.24 (0.24–0.24) 105,787
2 days to ≤3 days ( c ) 0.04 (0.04–0.04) 0.18 (0.18–0.18) 1,060,248 0.04 (0.04–0.04) 0.20 (0.20–0.20) 968,910
3 days to ≤4 days ( d ) 0.04 (0.04–0.04) 0.19 (0.19–0.19) 805,997 0.04 (0.04–0.04) 0.19 (0.19–0.19) 733,592
4 days to ≤5 days ( e ) 0.03 (0.03–0.03) 0.16 (0.16–0.16) 159,403 0.03 (0.03–0.03) 0.16 (0.16–0.16) 144,247
5 days to ≤6 days ( f ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 96,992 0.03 (0.03–0.03) 0.14 (0.14–0.14) 87,562
6 days to ≤7 days ( g ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 59,733 0.03 (0.03–0.03) 0.14 (0.14–0.14) 53,346
7 days to ≤8 days ( h ) 0.03 (0.03–0.03) 0.13 (0.13–0.13) 34,006 0.03 (0.03–0.03) 0.14 (0.14–0.14) 29,801
8 days to ≤9 days ( g ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 47,671 0.03 (0.03–0.03) 0.14 (0.14–0.14) 47,671
9 days to ≤10 days ( f ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 37,286 0.03 (0.03–0.03) 0.14 (0.14–0.14) 37,286
10 days to ≤11 days ( i ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 28,741 0.03 (0.03–0.03) 0.14 (0.14–0.14) 28,741
11 days to ≤12 days ( jk ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 26,452 0.03 (0.03–0.03) 0.14 (0.14–0.14) 26,452
12 days to ≤13 days ( j ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 23,708 0.03 (0.03–0.03) 0.14 (0.14–0.14) 23,708
13 days to ≤14 days ( k ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 21,671 0.03 (0.03–0.03) 0.14 (0.14–0.14) 21,671
C8 0 to ≤1 day ( a ) 0.03 (0.03–0.03) 0.10 (0.10–0.10) 10,324 0.03 (0.03–0.03) 0.08 (0.08–0.09) 9,600
1 day to ≤2 days ( b ) 0.03 (0.03–0.03) 0.10 (0.10–0.10) 116,325 0.03 (0.03–0.03) 0.10 (0.10–0.10) 105,728
2 days to ≤3 days ( c ) 0.03 (0.03–0.03) 0.10 (0.10–0.10) 1,057,935 0.03 (0.03–0.03) 0.10 (0.10–0.10) 968,607
3 days to ≤4 days ( d ) 0.03 (0.03–0.03) 0.10 (0.10–0.10) 803,824 0.02 (0.02–0.02) 0.09 (0.09–0.09) 732,597
4 days to ≤5 days ( e ) 0.02 (0.02–0.02) 0.08 (0.08–0.08) 159,554 0.02 (0.02–0.02) 0.08 (0.08–0.09) 144,322
5 days to ≤6 days ( f ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 97,166 0.02 (0.02–0.02) 0.07 (0.07–0.07) 87,734
6 days to ≤7 days ( g ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 59,908 0.02 (0.02–0.02) 0.07 (0.07–0.07) 53,429
7 days to ≤8 days ( g ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 34,094 0.02 (0.02–0.02) 0.07 (0.07–0.07) 29,832
8 days to ≤9 days ( g ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 25,516 0.02 (0.02–0.02) 0.07 (0.07–0.07) 22,257
9 days to ≤10 days (h) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 19,960 0.02 (0.02–0.02) 0.07 (0.07–0.07) 17,392
10 days to ≤11 days ( h ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 15,406 0.02 (0.02–0.02) 0.07 (0.07–0.07) 13,368
11 days to ≤12 days ( h ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 14,163 0.02 (0.02–0.02) 0.07 (0.07–0.07) 12,303
12 days to ≤13 days ( h ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 12,542 0.02 (0.02–0.02) 0.07 (0.07–0.07) 11,145
13 days to ≤14 days ( h ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 11,526 0.02 (0.02–0.02) 0.07 (0.07–0.07) 10,134
C8:1 0 to ≤1 day ( a ) 0.05 (0.05–0.05) 0.21 (0.21–0.21) 10,269 0.05 (0.05–0.05) 0.21 (0.21–0.21) 9,523
1 day to ≤2 days ( b ) 0.04 (0.04–0.04) 0.24 (0.24–0.24) 115,199 0.04 (0.04–0.04) 0.22 (0.22–0.22) 104,687
2 days to ≤3 days ( c ) 0.05 (0.05–0.05) 0.23 (0.23–0.23) 1,055,471 0.05 (0.05–0.05) 0.24 (0.24–0.25) 965,965
3 days to ≤4 days ( d ) 0.06 (0.06–0.06) 0.24 (0.23–0.24) 802,066 0.06 (0.06–0.06) 0.23 (0.23–0.23) 730,911
4 days to ≤5 days ( e ) 0.05 (0.05–0.05) 0.23 (0.23–0.23) 158,586 0.05 (0.05–0.05) 0.22 (0.22–0.22) 143,623
5 days to ≤6 days ( f ) 0.04 (0.04–0.04) 0.23 (0.23–0.24) 182,932 0.04 (0.04–0.04) 0.23 (0.23–0.24) 182,932
6 days to ≤7 days ( a ) 0.04 (0.04–0.04) 0.22 (0.21–0.22) 111,825 0.04 (0.04–0.04) 0.22 (0.21–0.22) 111,825
7 days to ≤8 days ( a ) 0.04 (0.04–0.04) 0.23 (0.23–0.23) 62,787 0.04 (0.04–0.04) 0.23 (0.23–0.23) 62,787
8 days to ≤9 days ( f ) 0.04 (0.04–0.04) 0.23 (0.23–0.23) 46,869 0.04 (0.04–0.04) 0.23 (0.23–0.23) 46,869
9 days to ≤10 days ( b ) 0.04 (0.04–0.04) 0.25 (0.25–0.25) 19,554 0.04 (0.04–0.04) 0.25 (0.25–0.25) 17,054
10 days to ≤11 days ( g ) 0.04 (0.04–0.04) 0.25 (0.25–0.26) 28,200 0.04 (0.04–0.04) 0.25 (0.25–0.26) 28,200
11 days to ≤12 days ( g ) 0.04 (0.04–0.04) 0.25 (0.24–0.25) 13,877 0.04 (0.04–0.04) 0.26 (0.26–0.26) 12,012
12 days to ≤13 days ( h ) 0.04 (0.04–0.04) 0.26 (0.26–0.26) 23,097 0.04 (0.04–0.04) 0.26 (0.26–0.26) 23,097
13 days to ≤14 days ( i ) 0.04 (0.04–0.04) 0.26 (0.25–0.26) 21,109 0.04 (0.04–0.04) 0.26 (0.25–0.26) 21,109
C10 0 to ≤1 day ( a ) 0.04 (0.04–0.04) 0.15 (0.15–0.15) 10,299 0.04 (0.04–0.05) 0.13 (0.13–0.14) 9,576
1 day to ≤2 days ( b ) 0.03 (0.03–0.03) 0.15 (0.15–0.15) 115,637 0.03 (0.03–0.03) 0.15 (0.15–0.15) 105,020
2 days to ≤3 days ( c ) 0.03 (0.03–0.03) 0.15 (0.15–0.15) 1,049,789 0.03 (0.03–0.03) 0.14 (0.14–0.14) 960,217
3 days to ≤4 days ( d ) 0.03 (0.03–0.03) 0.14 (0.14–0.14) 796,974 0.03 (0.03–0.03) 0.14 (0.14–0.14) 725,189
4 days to ≤5 days ( e ) 0.03 (0.03–0.03) 0.11 (0.10–0.11) 157,236 0.03 (0.03–0.03) 0.10 (0.10–0.10) 141,458
5 days to ≤6 days ( f ) 0.03 (0.03–0.03) 0.10 (0.10–0.10) 95,382 0.02 (0.02–0.03) 0.09 (0.09–0.09) 85,776
6 days to ≤7 days ( g ) 0.03 (0.03–0.03) 0.09 (0.09–0.09) 58,696 0.02 (0.02–0.02) 0.09 (0.09–0.09) 52,091
7 days to ≤8 days ( hi ) 0.02 (0.02–0.03) 0.09 (0.09–0.09) 33,339 0.02 (0.02–0.02) 0.09 (0.09–0.09) 29,119
8 days to ≤9 days ( ij ) 0.03 (0.02–0.03) 0.09 (0.09–0.09) 24,960 0.02 (0.02–0.02) 0.09 (0.09–0.09) 21,633
9 days to ≤10 days ( h ) 0.03 (0.02–0.03) 0.09 (0.09–0.09) 19,521 0.02 (0.02–0.02) 0.09 (0.09–0.09) 16,947
10 days to ≤11 days ( hi ) 0.03 (0.02–0.03) 0.09 (0.09–0.09) 15,069 0.03 (0.02–0.03) 0.09 (0.09–0.10) 13,070
11 days to ≤12 days ( hi ) 0.02 (0.02–0.02) 0.09 (0.09–0.09) 13,822 0.02 (0.02–0.02) 0.09 (0.09–0.10) 11,974
12 days to ≤13 days ( hij ) 0.03 (0.03–0.03) 0.09 (0.09–0.09) 12,301 0.02 (0.02–0.02) 0.09 (0.08–0.09) 10,882
13 days to ≤14 days ( j ) 0.03 (0.02–0.03) 0.09 (0.09–0.10) 11,279 0.03 (0.02–0.03) 0.09 (0.09–0.10) 9,930
C10:1 0 to ≤1 day ( a ) 0.04 (0.04–0.05) 0.11 (0.11–0.11) 10,349 0.03 (0.03–0.03) 0.11 (0.11–0.11) 9,616
1 day to ≤2 days ( b ) 0.03 (0.03–0.03) 0.13 (0.13–0.13) 112,727 0.03 (0.03–0.03) 0.14 (0.14–0.14) 105,727
2 days to ≤3 days ( c ) 0.03 (0.03–0.03) 0.13 (0.13-0.13) 1,051,125 0.03 (0.03-0.03) 0.13 (0.13-0.13) 970,613
3 days to ≤4 days ( d ) 0.03 (0.03-0.03) 0.14 (0.14-0.14) 802,987 0.03 (0.03-0.03) 0.14 (0.14-0.14) 733,977
4 days to ≤5 days ( e ) 0.03 (0.03-0.03) 0.13 (0.13-0.13) 158,657 0.03 (0.03-0.03) 0.11 (0.11-0.11) 144,566
5 days to ≤6 days ( f ) 0.03 (0.03-0.03) 0.11 (0.11-0.11) 96,022 0.03 (0.03-0.03) 0.12 (0.12-0.12) 87,892
6 days to ≤7 days ( g ) 0.03 (0.03-0.03) 0.12 (0.12-0.12) 59,493 0.02 (0.02-0.02) 0.11 (0.11-0.12) 53,565
7 days to ≤8 days ( hi ) 0.02 (0.02-0.02) 0.10 (0.10-0.10) 33,671 0.02 (0.02-0.02) 0.10 (0.10-0.10) 29,919
8 days to ≤9 days ( h ) 0.02 (0.02-0.02) 0.10 (0.10-0.10) 24,756 0.02 (0.02-0.02) 0.10 (0.10-0.10) 22,303
9 days to ≤10 days ( hi ) 0.02 (0.02-0.02) 0.10 (0.10-0.10) 19,493 0.02 (0.02-0.02) 0.10 (0.10-0.10) 17,439
10 days to ≤11 days ( ij ) 0.02 (0.02-0.02) 0.10 (0.10-0.10) 14,935 0.02 (0.02-0.02) 0.10 (0.09-0.10) 13,399
11 days to ≤12 days ( j ) 0.02 (0.02-0.03) 0.10 (0.10-0.10) 13,697 0.02 (0.02-0.02) 0.10 (0.10-0.10) 12,332
12 days to ≤13 days ( j ) 0.03 (0.03-0.03) 0.10 (0.10-0.10) 12,566 0.03 (0.02-0.03) 0.10 (0.10-0.10) 11,189
13 days to ≤14 days ( j ) 0.02 (0.02–0.02) 0.10 (0.10–0.10) 21,706 0.02 (0.02–0.02) 0.10 (0.10–0.10) 21,706
C12 0 to ≤1 day ( a ) 0.04 (0.04-0.04) 0.19 (0.18-0.19) 10,341 0.04 (0.04-0.04) 0.15 (0.14-0.15) 9,587
1 day to ≤2 days ( b ) 0.04 (0.04-0.04) 0.18 (0.18-0.18) 116,230 0.04 (0.04-0.04) 0.17 (0.17-0.17) 105,548
2 days to ≤3 days ( c ) 0.04 (0.04-0.04) 0.17 (0.17-0.17) 1,055,419 0.03 (0.03-0.03) 0.15 (0.15-0.15) 965,316
3 days to ≤4 days ( d ) 0.03 (0.03-0.03) 0.13 (0.13-0.13) 801,741 0.03 (0.03-0.03) 0.14 (0.14-0.14) 729,392
4 days to ≤5 days ( e ) 0.03 (0.03-0.03) 0.10 (0.10-0.10) 157,447 0.03 (0.03-0.03) 0.10 (0.10-0.10) 141,833
5 days to ≤6 days ( f ) 0.03 (0.03-0.03) 0.09 (0.09-0.09) 95,410 0.03 (0.02-0.03) 0.09 (0.09-0.09) 85,841
6 days to ≤7 days ( g ) 0.03 (0.03-0.03) 0.09 (0.09-0.09) 58,559 0.02 (0.02-0.02) 0.08 (0.08-0.08) 52,068
7 days to ≤8 days ( h ) 0.02 (0.02-0.02) 0.09 (0.08-0.09) 33,098 0.02 (0.02-0.02) 0.08 (0.08-0.08) 28,948
8 days to ≤9 days ( i ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 24,736 0.02 (0.02-0.02) 0.08 (0.08-0.08) 21,518
9 days to ≤10 days ( j ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 19,303 0.02 (0.02-0.02) 0.08 (0.08-0.08) 16,793
10 days to ≤11 days ( k ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 14,861 0.02 (0.02-0.02) 0.08 (0.08-0.08) 12,930
11 days to ≤12 days ( L ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 13,662 0.02 (0.02-0.02) 0.08 (0.08-0.08) 11,878
12 days to ≤13 days ( m ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 12,142 0.03 (0.03-0.03) 0.06 (0.06-0.06) 10,745
13 days to ≤14 days ( n ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 11,085 0.03 (0.03-0.03) 0.06 (0.06-0.06) 9,747
C12:1 0 to ≤1 day ( a ) 0.03 (0.03-0.03) 0.20 (0.19-0.20) 10,288 0.03 (0.03-0.04) 0.18 (0.17-0.18) 9,496
1 day to ≤2 days ( b ) 0.02 (0.02-0.02) 0.17 (0.17-0.17) 112,482 0.02 (0.02-0.02) 0.15 (0.15-0.15) 100,630
2 days to ≤3 days ( c ) 0.02 (0.02-0.02) 0.15 (0.15-0.15) 1,010,273 0.02 (0.02-0.02) 0.13 (0.13-0.13) 908,710
3 days to ≤4 days ( d ) 0.02 (0.02-0.02) 0.11 (0.11-0.11) 724,065 0.02 (0.02-0.02) 0.11 (0.11-0.11) 667,570
4 days to ≤5 days ( e ) 0.01 (0.01-0.01) 0.08 (0.08-0.08) 145,737 0.01 (0.01-0.01) 0.08 (0.08-0.08) 133,250
5 days to ≤6 days ( f ) 0.01 (0.01-0.01) 0.08 (0.08-0.08) 92,154 0.01 (0.01-0.01) 0.08 (0.08-0.08) 83,848
6 days to ≤7 days ( g ) 0.01 (0.01-0.01) 0.08 (0.08-0.08) 58,635 0.01 (0.01-0.01) 0.07 (0.07-0.07) 50,920
7 days to ≤8 days ( h ) 0.01 (0.01-0.01) 0.07 (0.07-0.07) 32,510 0.01 (0.01-0.01) 0.07 (0.07-0.07) 28,700
8 days to ≤9 days ( i ) 0.01 (0.01-0.01) 0.07 (0.07-0.07) 24,442 0.01 (0.01-0.01) 0.07 (0.07-0.07) 21,474
9 days to ≤10 days ( j ) 0.01 (0.01-0.01) 0.07 (0.07-0.07) 19,257 0.01 (0.01-0.01) 0.07 (0.07-0.07) 16,842
10 days to ≤11 days ( k ) 0.01 (0.01–0.01) 0.07 (0.07–0.08) 27,891 0.01 (0.01–0.01) 0.07 (0.07–0.08) 27,891
11 days to ≤12 days ( L ) 0.01 (0.01-0.01) 0.07 (0.07-0.08) 13,775 0.01 (0.01-0.01) 0.06 (0.06-0.06) 12,010
12 days to ≤13 days ( m ) 0.01 (0.01–0.01) 0.06 (0.06–0.06) 23,078 0.01 (0.01–0.01) 0.06 (0.06–0.06) 23,078
13 days to ≤14 days ( n ) 0.01 (0.01–0.01) 0.06 (0.06–0.06) 21,236 0.01 (0.01–0.01) 0.06 (0.06–0.06) 21,236
C14 0 to ≤1 day ( a ) 0.10 (0.09-0.10) 0.31 (0.31-0.31) 10,276 0.10 (0.10-0.11) 0.29 (0.29-0.30) 9,576
1 day to ≤2 days ( b ) 0.10 (0.10-0.10) 0.32 (0.32-0.32) 115,584 0.09 (0.09-0.09) 0.29 (0.29-0.29) 105,485
2 days to ≤3 days ( c ) 0.10 (0.10-0.10) 0.32 (0.32-0.32) 1,051,129 0.09 (0.09-0.09) 0.27 (0.27-0.27) 966,553
3 days to ≤4 days ( d ) 0.10 (0.10-0.10) 0.30 (0.30-0.30) 802,286 0.09 (0.09-0.09) 0.26 (0.26-0.26) 732,834
4 days to ≤5 days ( e ) 0.08 (0.08-0.08) 0.26 (0.26-0.26) 159,413 0.07 (0.07-0.07) 0.24 (0.24-0.24) 144,235
5 days to ≤6 days ( f ) 0.08 (0.08-0.08) 0.27 (0.27-0.28) 96,965 0.07 (0.07-0.07) 0.24 (0.24-0.24) 87,569
6 days to ≤7 days ( g ) 0.07 (0.07-0.07) 0.26 (0.26-0.27) 59,675 0.07 (0.07-0.08) 0.23 (0.23-0.23) 53,205
7 days to ≤8 days ( h ) 0.06 (0.06-0.07) 0.24 (0.24-0.24) 33,875 0.06 (0.06-0.06) 0.21 (0.21-0.21) 29,593
8 days to ≤9 days ( i ) 0.06 (0.06-0.06) 0.23 (0.23-0.23) 25,204 0.06 (0.06-0.06) 0.20 (0.20-0.20) 21,898
9 days to ≤10 days ( j ) 0.06 (0.06-0.06) 0.22 (0.22-0.22) 19,618 0.05 (0.05-0.05) 0.19 (0.18-0.19) 16,947
10 days to ≤11 days ( k ) 0.05 (0.05-0.05) 0.20 (0.20-0.20) 15,033 0.05 (0.05-0.05) 0.19 (0.19-0.20) 12,891
11 days to ≤12 days ( L ) 0.05 (0.05-0.05) 0.19 (0.19-0.19) 13,681 0.05 (0.05-0.05) 0.17 (0.17-0.17) 11,719
12 days to ≤13 days ( m ) 0.05 (0.05-0.05) 0.17 (0.17-0.17) 12,020 0.05 (0.05-0.06) 0.16 (0.16-0.16) 10,433
13 days to ≤14 days ( n ) 0.05 (0.05-0.05) 0.17 (0.16-0.17) 10,875 0.04 (0.04-0.04) 0.15 (0.15-0.15) 9,310
C14:1 0 to ≤1 day ( a ) 0.05 (0.05-0.05) 0.19 (0.19-0.20) 10,090 0.05 (0.05-0.05) 0.18 (0.17-0.18) 9,410
1 day to ≤2 days ( b ) 0.04 (0.04-0.04) 0.19 (0.19-0.19) 112,866 0.04 (0.04-0.04) 0.18 (0.18-0.18) 103,385
2 days to ≤3 days ( c ) 0.04 (0.04-0.04) 0.15 (0.15-0.15) 1,034,450 0.04 (0.04-0.04) 0.17 (0.17-0.17) 950,964
3 days to ≤4 days ( d ) 0.04 (0.04-0.04) 0.15 (0.15-0.15) 795,493 0.03 (0.03-0.03) 0.13 (0.13-0.13) 725,717
4 days to ≤5 days ( e ) 0.03 (0.03-0.03) 0.10 (0.10-0.10) 158,635 0.03 (0.03-0.03) 0.10 (0.10-0.10) 143,346
5 days to ≤6 days ( f ) 0.03 (0.03-0.03) 0.09 (0.09-0.09) 96,220 0.03 (0.03-0.03) 0.09 (0.09-0.09) 86,643
6 days to ≤7 days ( g ) 0.03 (0.03-0.03) 0.08 (0.08-0.08) 59,052 0.03 (0.03-0.03) 0.08 (0.08-0.08) 52,528
7 days to ≤8 days ( h ) 0.03 (0.03-0.03) 0.08 (0.08-0.08) 33,435 0.02 (0.02-0.03) 0.08 (0.08-0.08) 29,189
8 days to ≤9 days ( i ) 0.02 (0.02-0.03) 0.08 (0.08-0.08) 24,906 0.02 (0.02-0.02) 0.08 (0.08-0.08) 21,667
9 days to ≤10 days ( j ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 19,448 0.02 (0.02-0.02) 0.06 (0.06-0.06) 16,852
10 days to ≤11 days ( k ) 0.03 (0.03-0.03) 0.06 (0.06-0.06) 14,943 0.02 (0.02-0.02) 0.06 (0.06-0.06) 12,905
11 days to ≤12 days ( kl ) 0.03 (0.03-0.03) 0.06 (0.06-0.06) 13,685 0.02 (0.02-0.02) 0.07 (0.07-0.07) 11,850
12 days to ≤13 days ( k ) 0.02 (0.02-0.02) 0.06 (0.06-0.06) 12,109 0.02 (0.02-0.02) 0.07 (0.07-0.07) 10,701
13 days to ≤14 days ( L ) 0.02 (0.02–0.02) 0.07 (0.07–0.07) 20,766 0.02 (0.02–0.02) 0.07 (0.07–0.07) 20,766
C16 0 to ≤1 day ( a ) 1.55 (1.53-1.57) 4.97 (4.93-5.00) 10,319 1.50 (1.48-1.53) 4.75 (4.71-4.79) 9,593
1 day to ≤2 days ( b ) 1.47 (1.46-1.48) 5.31 (5.30-5.33) 116,204 1.38 (1.37-1.39) 4.96 (4.95-4.97) 105,744
2 days to ≤3 days ( c ) 1.45 (1.45-1.45) 5.51 (5.51-5.51) 1,054,703 1.35 (1.35-1.35) 5.14 (5.13-5.14) 968,021
3 days to ≤4 days ( d ) 1.33 (1.32-1.33) 5.28 (5.27-5.28) 802,507 1.25 (1.25-1.26) 4.94 (4.94-4.95) 732,751
4 days to ≤5 days ( e ) 1.09 (1.08-1.09) 4.50 (4.49-4.50) 159,501 1.02 (1.02-1.03) 4.20 (4.19-4.21) 144,473
5 days to ≤6 days ( f ) 0.97 (0.96-0.97) 3.86 (3.85-3.87) 97,154 0.91 (0.90-0.91) 3.61 (3.60-3.62) 87,762
6 days to ≤7 days ( g ) 0.87 (0.87-0.88) 3.34 (3.33-3.35) 59,798 0.80 (0.79-0.80) 3.10 (3.10-3.12) 53,291
7 days to ≤8 days ( h ) 0.77 (0.76-0.78) 2.98 (2.97-2.99) 33,940 0.72 (0.71-0.72) 2.76 (2.75-2.77) 29,596
8 days to ≤9 days ( i ) 0.70 (0.69-0.70) 2.70 (2.69-2.72) 25,243 0.67 (0.66-0.68) 2.50 (2.48-2.52) 21,916
9 days to ≤10 days ( j ) 0.64 (0.62-0.64) 2.49 (2.48-2.51) 19,549 0.60 (0.59-0.61) 2.27 (2.26-2.28) 16,879
10 days to ≤11 days ( k ) 0.59 (0.58-0.60) 2.23 (2.22-2.25) 14,862 0.56 (0.55-0.57) 2.06 (2.05-2.07) 12,735
11 days to ≤12 days ( L ) 0.55 (0.55-0.56) 2.03 (2.01-2.04) 13,404 0.52 (0.51-0.52) 1.86 (1.85-1.88) 11,440
12 days to ≤13 days ( m ) 0.51 (0.50-0.52) 1.88 (1.87-1.90) 11,545 0.49 (0.49-0.50) 1.71 (1.70-1.72) 9,973
13 days to ≤14 days ( n ) 0.48 (0.48-0.49) 1.71 (1.70-1.73) 10,263 0.46 (0.45-0.47) 1.56 (1.54-1.58) 8,624
C16:1 0 to ≤1 day ( a ) 0.07 (0.06-0.07) 0.36 (0.36-0.37) 10,346 0.07 (0.07-0.07) 0.33 (0.33-0.33) 9,602
1 day to ≤2 days ( b ) 0.07 (0.07-0.07) 0.36 (0.36-0.36) 116,328 0.07 (0.07-0.07) 0.34 (0.34-0.34) 105,855
2 days to ≤3 days ( c ) 0.07 (0.07-0.07) 0.36 (0.36-0.36) 1,057,815 0.06 (0.06-0.06) 0.33 (0.33-0.33) 969,526
3 days to ≤4 days ( d ) 0.06 (0.06-0.06) 0.32 (0.32-0.32) 804,706 0.06 (0.06-0.06) 0.30 (0.30-0.30) 733,932
4 days to ≤5 days ( e ) 0.05 (0.05-0.05) 0.25 (0.25-0.25) 159,884 0.04 (0.04-0.04) 0.22 (0.22-0.22) 144,775
5 days to ≤6 days ( f ) 0.04 (0.04-0.04) 0.18 (0.18-0.18) 97,437 0.04 (0.04-0.04) 0.17 (0.17-0.17) 88,045
6 days to ≤7 days ( g ) 0.04 (0.03-0.04) 0.15 (0.15-0.15) 60,085 0.03 (0.03-0.03) 0.14 (0.14-0.14) 53,651
7 days to ≤8 days ( h ) 0.03 (0.03-0.03) 0.14 (0.14-0.14) 34,226 0.03 (0.03-0.03) 0.12 (0.12-0.12) 29,973
8 days to ≤9 days ( i ) 0.03 (0.03-0.03) 0.12 (0.12-0.12) 25,596 0.03 (0.03-0.03) 0.11 (0.11-0.11) 22,347
9 days to ≤10 days ( j ) 0.03 (0.03-0.03) 0.11 (0.11-0.11) 20,021 0.03 (0.03-0.03) 0.10 (0.10-0.10) 17,461
10 days to ≤11 days ( k ) 0.03 (0.03-0.03) 0.10 (0.10-0.10) 15,462 0.02 (0.02-0.02) 0.09 (0.09-0.09) 13,416
11 days to ≤12 days ( L ) 0.02 (0.02-0.02) 0.09 (0.09-0.09) 14,205 0.02 (0.02-0.02) 0.08 (0.08-0.08) 12,341
12 days to ≤13 days ( m ) 0.02 (0.02-0.02) 0.09 (0.09-0.10) 12,566 0.02 (0.02-0.02) 0.08 (0.08-0.08) 11,183
13 days to ≤14 days ( n ) 0.02 (0.02-0.02) 0.08 (0.08-0.08) 11,545 0.02 (0.02-0.02) 0.07 (0.07-0.07) 10,146
C16:1-OH 0 to ≤1 day ( a ) 0.02 (0.02-0.02) 0.05 (0.05-0.05) 9,569 0.02 (0.02-0.02) 0.05 (0.05-0.05) 9,225
1 day to ≤2 days ( b ) 0.02 (0.02-0.02) 0.07 (0.07-0.07) 115,989 0.02 (0.02-0.02) 0.05 (0.05-0.05) 99,821
2 days to ≤3 days ( c ) 0.02 (0.02-0.02) 0.05 (0.05-0.05) 980,322 0.02 (0.02-0.02) 0.05 (0.05-0.05) 928,315
3 days to ≤4 days ( d ) 0.02 (0.02-0.02) 0.05 (0.05-0.05) 754,726 0.02 (0.02-0.02) 0.05 (0.05-0.05) 705,462
4 days to ≤5 days ( e ) 0.02 (0.02-0.02) 0.05 (0.05-0.05) 149,642 0.02 (0.02-0.02) 0.06 (0.06-0.06) 144,347
5 days to ≤6 days ( f ) 0.02 (0.02-0.02) 0.05 (0.05-0.05) 90,618 0.01 (0.01-0.01) 0.06 (0.06-0.06) 87,648
6 days to ≤7 days ( g ) 0.01 (0.01-0.01) 0.06 (0.06-0.06) 59,576 0.01 (0.01-0.01) 0.05 (0.05-0.06) 53,456
7 days to ≤8 days ( h ) 0.01 (0.01-0.01) 0.06 (0.06-0.06) 33,962 0.01 (0.01-0.01) 0.04 (0.04-0.04) 27,784
8 days to ≤9 days ( i ) 0.01 (0.01-0.01) 0.04 (0.04-0.04) 23,435 0.01 (0.01-0.01) 0.04 (0.04-0.04) 20,989
9 days to ≤10 days ( j ) 0.01 (0.01-0.01) 0.04 (0.04-0.04) 18,652 0.01 (0.01-0.01) 0.04 (0.04–0.04) 16,597
10 days to ≤11 days ( k ) 0.01 (0.01-0.01) 0.04 (0.04-0.04) 14,641 0.01 (0.01-0.01) 0.04 (0.04-0.04) 12,863
11 days to ≤12 days ( L ) 0.01 (0.01-0.01) 0.04 (0.04-0.04) 13,595 0.01 (0.01-0.01) 0.04 (0.04-0.04) 11,999
12 days to ≤13 days ( m ) 0.01 (0.01-0.01) 0.04 (0.04-0.04) 12,103 0.01 (0.01-0.01) 0.04 (0.04-0.04) 10,907
13 days to ≤14 days ( n ) 0.01 (0.01-0.01) 0.04 (0.04-0.04) 11,202 0.01 (0.01-0.01) 0.04 (0.04-0.04) 9,936
C18 0 to ≤1 day ( a ) 0.47 (0.46-0.48) 1.34 (1.33-1.35) 10,309 0.47 (0.47-0.48) 1.31 (1.30-1.32) 9,580
1 day to ≤2 days ( b ) 0.46 (0.46-0.46) 1.42 (1.42-1.43) 115,826 0.45 (0.45-0.45) 1.37 (1.37-1.37) 105,360
2 days to ≤3 days ( c ) 0.46 (0.46-0.46) 1.44 (1.44-1.44) 1,052,773 0.44 (0.43-0.44) 1.40 (1.40-1.40) 964,779
3 days to ≤4 days ( d ) 0.43 (0.43-0.43) 1.39 (1.39-1.39) 801,080 0.42 (0.42-0.42) 1.34 (1.34-1.34) 730,502
4 days to ≤5 days ( e ) 0.37 (0.37-0.37) 1.24 (1.24-1.24) 158,855 0.37 (0.37-0.38) 1.21 (1.21-1.22) 143,811
5 days to ≤6 days ( f ) 0.34 (0.33-0.34) 1.16 (1.16-1.17) 96,492 0.34 (0.34-0.34) 1.12 (1.11-1.12) 87,141
6 days to ≤7 days ( g ) 0.32 (0.32-0.32) 1.08 (1.08-1.08) 59,184 0.31 (0.30-0.31) 1.06 (1.06-1.07) 52,787
7 days to ≤8 days ( h ) 0.30 (0.30-0.30) 1.01 (1.01-1.02) 33,424 0.29 (0.28-0.29) 0.98 (0.98-0.99) 29,241
8 days to ≤9 days ( i ) 0.28 (0.28-0.28) 0.95 (0.95-0.95) 24,755 0.28 (0.28-0.29) 0.94 (0.94-0.95) 21,557
9 days to ≤10 days ( j ) 0.27 (0.27-0.27) 0.91 (0.91-0.92) 19,096 0.26 (0.25-0.26) 0.91 (0.90-0.91) 16,643
10 days to ≤11 days ( k ) 0.25 (0.24–0.25) 0.87 (0.86–0.87) 27,104 0.25 (0.24–0.25) 0.87 (0.86–0.87) 27,104
11 days to ≤12 days ( L ) 0.24 (0.24–0.24) 0.83 (0.82–0.83) 24,437 0.24 (0.24–0.24) 0.83 (0.82–0.83) 24,437
12 days to ≤13 days ( m ) 0.23 (0.23–0.23) 0.79 (0.79–0.79) 21,305 0.23 (0.23–0.23) 0.79 (0.79–0.79) 21,305
13 days to ≤14 days ( n ) 0.22 (0.22–0.22) 0.77 (0.77–0.78) 18,900 0.22 (0.22–0.22) 0.77 (0.77–0.78) 18,900
C18:1 0 to ≤1 day ( a ) 0.71 (0.70-0.73) 2.01 (2.00-2.02) 10,304 0.68 (0.67-0.68) 1.90 (1.89-1.92) 9,577
1 day to ≤2 days ( b ) 0.79 (0.79-0.79) 2.20 (2.20-2.21) 115,614 0.74 (0.73-0.74) 2.06 (2.06-2.07) 105,331
2 days to ≤3 days ( c ) 0.83 (0.82-0.83) 2.34 (2.34-2.34) 1,045,139 0.78 (0.78-0.78) 2.18 (2.18-2.18) 962,034
3 days to ≤4 days ( d ) 0.84 (0.84-0.84) 2.35 (2.34-2.35) 792,953 0.78 (0.78-0.78) 2.20 (2.20-2.20) 727,544
4 days to ≤5 days ( e ) 0.78 (0.77-0.78) 2.26 (2.26-2.26) 157,938 0.72 (0.71-0.72) 2.09 (2.08-2.09) 143,612
5 days to ≤6 days ( f ) 0.73 (0.73-0.73) 2.17 (2.16-2.17) 96,355 0.68 (0.67-0.68) 2.01 (2.01-2.02) 87,431
6 days to ≤7 days ( g ) 0.68 (0.67-0.68) 2.05 (2.05-2.06) 59,614 0.63 (0.62-0.63) 1.87 (1.86-1.87) 53,262
7 days to ≤8 days ( h ) 0.63 (0.62-0.63) 1.94 (1.94-1.95) 33,926 0.59 (0.59-0.60) 1.78 (1.78-1.79) 29,696
8 days to ≤9 days ( i ) 0.58 (0.58-0.59) 1.81 (1.81-1.82) 25,292 0.54 (0.54-0.55) 1.67 (1.67-1.68) 21,961
9 days to ≤10 days ( j ) 0.53 (0.52-0.53) 1.72 (1.71-1.73) 19,654 0.50 (0.50-0.51) 1.57 (1.56-1.58) 16,968
10 days to ≤11 days ( k ) 0.48 (0.47-0.48) 1.57 (1.56-1.58) 14,968 0.45 (0.44-0.45) 1.47 (1.46-1.48) 12,776
11 days to ≤12 days ( L ) 0.45 (0.44-0.46) 1.49 (1.49-1.50) 13,496 0.43 (0.42-0.43) 1.37 (1.36-1.38) 11,475
12 days to ≤13 days ( m ) 0.43 (0.42-0.43) 1.38 (1.37-1.39) 11,700 0.40 (0.39-0.40) 1.30 (1.29-1.31) 10,078
13 days to ≤14 days ( n ) 0.41 (0.41-0.42) 1.31 (1.30-1.32) 10,503 0.38 (0.38-0.39) 1.22 (1.21-1.23) 8,831
C18:2 0 to ≤1 day ( a ) 0.07 (0.07-0.07) 0.36 (0.36-0.36) 10,352 0.06 (0.05-0.06) 0.34 (0.34-0.35) 9,600
1 day to ≤2 days ( b ) 0.08 (0.08-0.08) 0.42 (0.42-0.42) 116,622 0.07 (0.07-0.07) 0.38 (0.38-0.38) 105,882
2 days to ≤3 days ( c ) 0.08 (0.08-0.08) 0.43 (0.43-0.43) 1,060,123 0.07 (0.07-0.07) 0.40 (0.40-0.40) 969,624
3 days to ≤4 days ( d ) 0.09 (0.09-0.09) 0.49 (0.48-0.49) 804,682 0.08 (0.08-0.08) 0.44 (0.44-0.44) 733,626
4 days to ≤5 days ( e ) 0.12 (0.12-0.12) 0.59 (0.58-0.59) 159,056 0.10 (0.10-0.10) 0.52 (0.52-0.52) 144,427
5 days to ≤6 days ( f ) 0.13 (0.12-0.13) 0.62 (0.61-0.62) 96,614 0.12 (0.12-0.12) 0.55 (0.54-0.55) 87,776
6 days to ≤7 days ( g ) 0.14 (0.14-0.14) 0.59 (0.59-0.59) 59,706 0.12 (0.12-0.12) 0.54 (0.54-0.54) 53,516
7 days to ≤8 days ( h ) 0.14 (0.13-0.14) 0.57 (0.57-0.57) 34,021 0.12 (0.12-0.12) 0.52 (0.52-0.52) 29,899
8 days to ≤9 days ( i ) 0.13 (0.13-0.13) 0.55 (0.55-0.56) 25,492 0.12 (0.12-0.13) 0.50 (0.50-0.50) 22,309
9 days to ≤10 days ( j ) 0.12 (0.11-0.12) 0.53 (0.52-0.53) 19,955 0.11 (0.11-0.11) 0.48 (0.47-0.48) 17,440
10 days to ≤11 days ( k ) 0.12 (0.12-0.12) 0.50 (0.50-0.50) 15,427 0.11 (0.11-0.11) 0.47 (0.47-0.48) 13,408
11 days to ≤12 days ( L ) 0.12 (0.12-0.13) 0.48 (0.47-0.48) 14,181 0.11 (0.11-0.12) 0.46 (0.46-0.47) 12,341
12 days to ≤13 days ( m ) 0.11 (0.10-0.11) 0.48 (0.48-0.49) 12,559 0.10 (0.09-0.10) 0.43 (0.43-0.44) 11,185
13 days to ≤14 days ( m ) 0.11 (0.10-0.11) 0.46 (0.46-0.46) 11,542 0.10 (0.09-0.10) 0.44 (0.44-0.45) 10,155
a

For each analyte, the bold and italic letter in the blanket indicates the difference between any two age partitions; same letter or letters shared in common means no significant difference and vice versa.

b

Boldfaced partitions indicate sex-specific difference within the age partitions and vice versa. If no statistical difference was found between males and females with the age partitions, data were combined and RIs, re-estimated.

c

Abbreviations: ALA, alanine; ARG, arginine; CIT, citrulline; GLY, glycine; LEU, leucine; ILE, isoleucine; ALLO-ILE, alloisoleucine; PRO-OH, hydroxyproline; MET, methionine; ORN, ornithine; PHE, phenylalanine; PRO, proline; TYR, tyrosine; VAL, valine; C0, free carnitine; C2, acetylcarnitine; C3, propionylcarnitine; C3-DC + C4-OH, malonylcarnitine+3-hydroxybutyrylcarnitine; C4, butyrylcarnitine + isobutyrylcarnitine; C4-DC + C5-OH, methylmalonylcarnitine+3-hydroxyisovalerylcarnitine; C5, isovalerylcarnitine + methylbutyrylcarnitine; C5-DC + C6-OH, glutarylcarnitine+3-hydroxyhexanoylcarnitine; C6, hexanoylcarnitine; C6-DC, methylglutarylcarnitine; C8, octanoylcarnitine; C8:1, octenoylcarnitine; C10, decanoylcarnitine; C10:1, decenoylcarnitine; C12, dodecanoylcarnitine; C12:1, dodecenoylcarnitine; C14, tetradecanoylcarnitine; C14:1, tetradecenoylcarnitine; C16, palmitoylcarnitine; C16:1, palmitoleylcarnitine; C16:1-OH, 3-hydroxypalmitoleylcarnitine; C18, stearoylcarnitine; C18:1, oleoylcarnitine; C18:2, linoleoylcarnitine.