Table 3.
Adverse events between TACE group and HAIC group.
| TACE group (n = 68) | HAIC group (n = 92) | |||||
|---|---|---|---|---|---|---|
| Grade 1-2 | Grade 3-4 | Grade 1-2 | Grade 3-4 | |||
| n (%) | n (%) | n (%) | P value | n (%) | P value | |
| Adverse event | 28 (41.2) | 6 (8.8) | 39 (42.4) | 0.878 | 4 (4.3) | 0.248 |
| Blood/bone marrow suppression | ||||||
| Leukopenia | 8 (11.8) | 1 (1.5) | 3 (3.3) | 0.036 | NA | 0.418 |
| Neutropenia | 6 (8.8) | 1 (1.5) | 4 (4.3) | 0.248 | NA | 0.418 |
| Reduced hemoglobin | 2 (2.9) | NA | 1 (1.1) | 0.575 | NA | 1.000 |
| Coagulation disorder | 2 (2.9) | NA | 1 (1.1) | 0.575 | NA | 1.000 |
| Elevated INR | 7 (10.3) | NA | 3 (3.3) | 0.069 | 1 (1.1) | 0.418 |
| Constitutional symptom | ||||||
| Weight loss | 16 (23.5) | NA | 14 (15.2) | 0.183 | NA | 1.000 |
| Fever | 11 (16.2) | NA | 11 (12.0) | 0.444 | NA | 1.000 |
| Fatigue | 6 (8.8) | NA | 10 (10.9) | 0.670 | NA | 1.000 |
| GI disorder | ||||||
| Ascites | 11 (16.2) | 1 (1.5) | 12 (13.0) | 0.577 | 2 (2.2) | 1.000 |
| Diarrhea | 2 (2.9) | NA | 1 (1.1) | 0.575 | NA | 1.000 |
| Anorexia | 2 (2.9) | NA | 1 (1.1) | 0.575 | NA | 1.000 |
| Constipation | 4 (5.9) | NA | NA | 0.031 | NA | 1.000 |
| Vomiting | 6 (8.8) | NA | 3 (3.3) | 0.131 | NA | 1.000 |
| Pain | ||||||
| Abdominal nonspecific | 3 (2.3) | NA | NA | NA | 1.000 | |
| Right shoulder back | NA | 2 (2.9) | 1(1.1) | NA | 0.179 | |
| Laboratory abnormalities | ||||||
| Elevated ALT | 26 (38.2) | 2 (2.9) | 31 (33.7) | 0.553 | 1 (1.1) | 0.575 |
| Elevated AST | 29 (42.6) | 1 (1.5) | 22 (23.9) | 0.012 | NA | 0.418 |
| Elevated TBIL | 12 (17.6) | NA | 12 (13.0) | 0.420 | NA | 1.000 |
| Elevated creatinine | 9 (13.2) | NA | 11 (12.0) | 0.809 | NA | 1.000 |
| Anaemia | 2 (2.9) | NA | NA | 0.179 | NA | 1.000 |
| Others | 10 (14.) | NA | 5 (5.4) | 0.047 | NA | 1.000 |
Data in bracket was percent of patients. The data in two groups were compared by using the Chi square test. *Data were compared by using Fisher’s exact test. TACE, transarterial chemoembolization; HAIC, hepatic arterial infusion chemotherapy; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GI, gastrointestinal; INR, international normalized ratio; TBIL, total bilirubin.