Table 4.
Results of the univariable and multivariable Cox regression model with regard to OS.
| Variable | Univariable Model | Multivariable Model | ||||
|---|---|---|---|---|---|---|
| Before PSM | After PSM | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (continuous) | 0.661 (0.383, 1.133) | 0.132 | – | – | – | – |
| Gender (male) | 1.459 (0.765, 2.782) | 0.252 | – | – | – | – |
| Comorbidities (presence) | 1.049 (0.620, 1.775) | 0.859 | – | – | – | – |
| Tumor size (continuous) | 1.225 (0.887, 1.777) | 0.200 | – | – | – | – |
| No. of tumors (multiple) | 0.903 (0.577, 1.412) | 0.654 | – | – | – | – |
| HBV (absence) | 1.492 (0.867, 2.567) | 0.149 | – | – | – | – |
| ALBI grade (2) | 1.363 (0.965, 1.925) | 0.079 | 1.652 (1.164, 2.345) | 0.005 | 1478 (1.140, 2.378) | 0.007 |
| PVTT (absence) | 1.402 (0.978, 2.010) | 0.066 | – | – | – | – |
| Metastasis (absence) | 0.843 (0.598, 1.189) | 0.331 | – | – | – | – |
| AFP (≥400 ng/ml) | 1.370 (0.945, 1.986) | 0.097 | – | – | – | – |
| Sessions (>3) | 0.514 (0.354, 0.747) | <0.001 | 0.389 (0.248, 0.609) | <0.001 | 0.497 (0.268, 0.752) | <0.001 |
| Treatment modalities | 1.132 (0.769, 1.610) | 0.490 | 0.401 (0.259, 0.621) | <0.001 | 0.415 (0.262, 0.771) | <0.001 |
| HAIC | ||||||
| TACE | ||||||
| Treatment responds | ||||||
| PR | – | – | – | – | – | – |
| SD | 0.248 (0.157, 0.391) | <0.001 | 0.409 (0.255, 0.606) | <0.001 | 0.415 (0.252, 0.609) | <0.001 |
| PD | 0.523 (0.337, 0.812) | 0.004 | 0.388 (0.248, 0.608) | <0.001 | 0.382 (0.243, 0.611) | <0.001 |
OS, overall survival; HR, hazard ratio; CL, confidence interval; PSM, propensity score match; TACE, transarterial chemoembolization; HAIC, hepatic arterial infusion chemotherapy; HBV, hepatitis B virus; CTP, child-turcotte-pugh; AFP, α-fetoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TBIL, total bilirubin; ALB, albumin.