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Schematic diagram of mechanisms by which m6A modification regulates non-self RNA recognition and innate immune responses. m6A modification in exogenous RNA prevent it from being identified by RNA sensors except for ISG20. Nuclear exportation of MAVS, TRAF3/6, p65, IKKγ, CGAS, and STING mRNA can be accelerated by m6A modification. m6A decoration may be an obstacle to IFNβ and ISGs expression. PTEN, p65 and IKKγ mRNA instability can also be attributed to m6A modification.
